血清CA125及NSE测定对肺癌的诊断价值  

The value of serum CA125 and NSE assays in the diagnosis of lung cancer

作　　者：王丽萍[1] 牛秋梅[1] 高国谦[1] 梅其达[1] 王瑞林[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,河南郑州450052

出　　处：《河南大学学报（医学科学版）》2002年第2期20-21,共2页

基　　金：河南省郑州市自然科学基金项目 (2 0 0 0 15 )

摘　　要：目的 :观察血清CA12 5、NSE测定对肺癌的诊断价值。方法 :采用放射免疫分析法对 5 1例肺癌患者和 32例肺良性疾病患者和 6 8例健康人进行血清CA12 5、NSE水平测定。结果 :发现肺癌患者血清CA12 5、NSE水平明显高于肺良性疾病组和正常对照组 (P <0 .0 0 1) ;其增高的程度与肺癌TNM分期具有一定的相关性。血清CA12 5及NSE测定诊断肺癌的敏感性为 6 2 .72 %及 4 9.0 2 % ;特异性为 99%及 98%。结论 :联合检测血清CA12 5及NSE对肺癌的诊断、分期及疗效判断具有重要的临床价值。Objectiv: To observe value of serum CA125 and NSE assays in the diagnosis of lung cancer. Methods: Contents of serum CA125? NSE were detected by immunoradiometric assay in lung cancer group (51 cases),benign pulmonary diseases(32 cases )and normal control group(68cases). Results: The serum CA125 ? NSE in lung cancer group were significantly higher than those in benign pulmonary diseases group and normal control group ( P <0.001). The degree of increase was directly associated with the lung cancer TNM stage. The sensitivity of serum CA125 and NSE assay in the diagnoses of lung cancer were 62.75% and 49.02% ;the specificity was 99% and 98%. Conclusion:Detection of serum CA125 and NSE is of clinical value for the diagnosis, staging and prognosis in lung cancer.

关 键 词：血清 肺癌 诊断 癌蛋白125 神经元特异性烯醇化酶 放射免疫分析法 

分 类 号：R734.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]