海洛因中毒性脑病的临床与影像学观察  

Clinical and image features of toxic encephalopathy induced by inhaling heroin

作　　者：许楚芸[1] 魏丽玲[1] 吴育彬[1] 

机构地区：[1]汕头大学医学院第一附属医院神经内科,515041

出　　处：《中华神经科杂志》2002年第4期224-226,共3页Chinese Journal of Neurology

摘　　要：目的　研究海洛因所致中毒性脑病的临床特点及影像学 (CT和MRI)特征。方法　对13例海洛因中毒性脑病患者的临床和影像学资料进行观察和分析。结果　 13例均为男性 ,均以烫吸海洛因为吸毒方式 ,9例是在毒品戒断过程中发病。主要临床表现为亚急性起病的弥漫性脑损害 ,尤以精神症状和小脑性共济失调为突出表现。 13例CT表现为脑内多发、广泛且明显对称性的低密度灶 ,累及双额、顶、颞、枕叶白质区及小脑半球齿状核和脑干 ,一般无占位征象。 6例同期MRI检查显示病灶的部位、范围与CT所见大致相同。结论　本病的诊断依靠明确烫吸海洛因史及具有特征性的临床表现和影像学征象。CT与MRI一样 ,对本病的诊断具有重要价值。激素对本病治疗效果差。Objective To study clinical manifestations and imagine features (CT and MRI) on toxic encephalopathy after inhaling heroin. Methods 13 patients with toxic encephalopathy induced by inhaling heroin were observed and analyzed on its clinical and imagine features (CT and MRI).Results 13 patients all were male, and were intoxicated by way of inhaling heroin vapour. Nine cases had appearances of clinical manifestations during abrupt abstinence. The main clinical manifestations of the disease were of the sub-acute diffuse cerebral lesions, especially of early mental symptoms and cerebellum ataxia. The CT of all 13 cases showed multiple white matter lesions involving in the frontal, parietal, occipital,temporal, and cerebellum hemisphere dentate nucleus. There was no occupational mass shown in general. The MRI of 6 cases showing focus was the same as of the CT. Conclusion The diagnosis of HTE should be dependent on the definite inhaling heroin vapour and their clinical features and neuroradiological appearance. CT should be valuable for the diagnosis of HTE, and the MRI as well. Corticosteroids show less therapeutic effect on such diesease.

关 键 词：海洛因中毒性脑病 临床特点 影像学表现 

分 类 号：R747.9[医药卫生—神经病学与精神病学]