VEGF及受体在颌面部血管瘤和血管畸形中表达及意义  

Expression and significance of VEGF and KDR in maxillofacial hemangiomas and vascularmlformations

作　　者：常健[1] 周中华[2] 徐晓刚[2] 江中明[2] 

机构地区：[1]济南军区总医院口腔科,山东济南250031 [2]第二军医大学长海医院口腔科

出　　处：《临床口腔医学杂志》2002年第5期343-345,共3页Journal of Clinical Stomatology

摘　　要：目的 检测细胞因子血管内皮生长因子(VEGF),血管内皮生长因子受体(VEGFR/KDR)及VEGF mRNA在颌面部血管瘤和血管畸形中的表达,探讨VEGF及其受体与血管瘤发病机制的关系。方法 采用二步EnVision免疫组织化学方法,分别检测27例血管瘤和15例血管畸形组织中VEGF和VEGF/KDR表达;同时采用原位杂交Gene Point法检测VEGF mRNA的表达。结果 VEGF和VEGFR/KDR在血管瘤中高表达,而在血管畸形组中低表达,两者有显著差异(P<0.01);VEGF和VEGF mRNA在血管瘤细胞及周围间质细胞明显表达,VEGFR/KDR主要表达于血管瘤中内皮细胞膜上。结论 VEGF可通过自分泌和旁分泌的形式影响血管瘤内皮细胞的增殖,可能与血管瘤发生、发展和退化有密切相关。Objective To investigate the correlation between the expression of VEGF and KDR and pathogenesis of hemangiomas with examining the expression of VEGF and KDR in maxillofacial hemangiomas and vasculamlformations. Methods VEGF and KDR were examined respectively in tissue sections from 27 cases with hemangiomas and 15 cases with vasculamlformations by the En Vision immumohistochemistry , and VEGF mRNA was examined in situ hybridization in those tissue. Results The expressions of VEGF and KDR in hemangiomas were higher than that of invas-cularmlformations, VEGF and VEGF mRNA were expressed mainly on endothelial cells and pericytes of hemangiomas, KDR was experessed on endothelial cells. Conclusion There is potential role between expressions of VEGF and its receptor with the pathogenesis and regression of maxillofacial hemangiomas.

关 键 词：颌面部血管瘤 VEGF VEGFR 内皮细胞 血管畸形 血管内皮细胞生长因子 血管内皮细胞生长因子受体 

分 类 号：R739.81[医药卫生—肿瘤]