PVP方案术前诱导化疗对口腔鳞癌的近期疗效  

Short term efficient evaluation of preoperative inductive combined chemotherapy with CDDP, VCR and PYM in the treatment of oral squamous cell carcinoma.

作　　者：杨建平[1] 刘美绸[1] 刘贻庆[1] 

机构地区：[1]市第一医院口腔颌面外科,福建三明365000

出　　处：《临床口腔医学杂志》2002年第5期364-365,共2页Journal of Clinical Stomatology

摘　　要：目的 对PVP方案术前诱导化疗治疗口腔鳞癌的近期疗效及安全性进行评价。方法 16例口腔鳞癌,均采用PVP方案化疗即CDDP 100mg/m^2)+VCR 2mg+PYM 80mg,化疗结束后第10天,手术前,按照国际通用标准,进行近期疗效的评定,对药物毒副作用进行观察。结果 治疗口腔鳞癌16例,近期有效率(缓解率)为93.75％。化疗的主要毒副作用为呕吐、脱发、骨髓抑制等。结论 以大剂量顺铂为主的联合化疗(PVP)方案,术前诱导化疗的近期疗效显著,在晚期口腔鳞癌的综合治疗中可推广应用,化疗中严格执行水化和利尿的原则,可提高化疗的安全性。Objective To evaluate the short term effect of preoperative inductive combined chemotherapy with PVP in the treatment of oral squamous cell carcinoma. Methods PVP combined chemotherapy was used in 16 cases with oral squamous carcinoma, when chemotherapy had finished, Befort operation the short term curative effect was evaluated according to international standard and side effect of the drugs were observed. Results The short term curative rate of PVP in the case with oral squamous carcinoma was 93.75%. The main side effect of the chemotherapy was vomit, hair drop and arrest of bone marrow etc. Conclusion The preoperation inductive combined chemotherapy with PVP is feasible for the treatment of oral squamous cell carcinoma.

关 键 词：PVP方案 近期疗效 口腔鳞状细胞癌 术前诱导化疗 顺铂 

分 类 号：R739.8[医药卫生—肿瘤]