Joint effect among p53,CYPIA1,GSTM1 polymorphism combinations and smoking on prostate cancer risk:an exploratory genotype-environment interaction study  

p53、CYP1A1、GSTM1多态性组合和吸烟对前列腺癌风险的联合效应:基因型和环境相互作用的探测性研究

作　　者：LuisA.Quiones CarlosE.Irarrzabal ClaudioR.Rojas CristianE.Orellana CristianAcevedo ChristianHuidobro Nelson E.Varela DanteD.Cáceres 

机构地区：[1]Laboratory of Chemical Carcinogenesis and Pharmacogenetics,Faculty of Medicine,Biomedical Science Institute(ICBM),University of Chile,Independencia 1027,Santiago,Chile [2]Department [3]Epidemiology Division,School of Public Health,Faculty of Medicine,University of Chile,Independencia 939,Santiago,Chile [4]Laboratory of Chemical Carcinogenesis and Pharmacogenetics,Faculty of Medicine,Biomedical Science Institute(ICBM),University of Chile,Independencia 1027,Santiago.Chile

出　　处：《Asian Journal of Andrology》2006年第A03期349-355,389,共5页亚洲男性学杂志（英文版）

摘　　要：Aim:To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk.We focus on allele variants of low-penetrance genes associated with cell control,the detoxifica- tion processes and smoking.Methods:In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk.Results:The joint risk for smokers carrying Pro* and Ml*,Pro* and GSTMlnull or GSTM1 null and CYP1A1 Ml* variants was significantly higher (odds ratio [OR]:13.13.95% confidence interval [CI]:2.41-71.36;OR:3.97,95% CI:1.13-13.95 and OR:6.87. 95% CI:1.68-27.97,respectively)compared with that for the reference group,and for non-smokers was not significant. OR for combinations among p53cd72,GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group(OR:8.87,95% CI:1.25-62.71).Conclusion:Our results suggest that a combination of p53cd72,CYP1A1,GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population,which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.Aim:To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk.We focus on allele variants of low-penetrance genes associated with cell control,the detoxifica- tion processes and smoking.Methods:In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk.Results:The joint risk for smokers carrying Pro* and Ml*,Pro* and GSTMlnull or GSTM1 null and CYP1A1 Ml* variants was significantly higher (odds ratio [OR]:13.13.95% confidence interval [CI]:2.41-71.36;OR:3.97,95% CI:1.13-13.95 and OR:6.87. 95% CI:1.68-27.97,respectively)compared with that for the reference group,and for non-smokers was not significant. OR for combinations among p53cd72,GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group(OR:8.87,95% CI:1.25-62.71).Conclusion:Our results suggest that a combination of p53cd72,CYP1A1,GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population,which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.

关 键 词：p53cd72 GSTMI CYPIAI genetic polymorphism prostate cancer risk SMOKING 

分 类 号：R737.25[医药卫生—肿瘤]