柴胡对癫痫模型电活动的调制  

MODULATION WITH BUPLEURUM ROOT ON BRAIN ELECTRICAL ACTIVITIES IN EPILEPTIC MODEL

作　　者：徐淑梅[1] 郑开俊[1] 何津岩[1] 仇晓菁[1] 林来祥[1] 

机构地区：[1]天津医科大学生理教研室,天津300070

出　　处：《中国应用生理学杂志》2002年第3期294-296,共3页Chinese Journal of Applied Physiology

基　　金：天津市 21世纪 青年科学基金资助项目(963 70 8411)

摘　　要：目的 :研究柴胡对癫痫发作的影响。方法 :以家兔和大鼠为实验对象 ,用毛果芸香碱致痫 ,采用脑电图和细胞外玻璃微电极记录技术 ,观察柴胡对癫痫模型大脑皮层放电及海马脑片场电位的影响。结果 :腹腔注射柴胡后可使癫痫发作次数及发作持续时间显著减少 ,发作间隔时间显著延长 ,(P <0 .0 5 ) ,脑片旁滴注柴胡后使致痫大鼠海马脑片诱发场电位幅度平均降低 2 0 .4 1% ,恢复时间平均为 6 .86min ,(P <0 .0 1)。结论 :柴胡注射液能明显抑制癫痫模型电活动 。Aim: To study the effect of bupleurum root on epileptic seizure. Methods: The rabbits and rats were injected by pilocarpine as epileptic models, and observed the effect of bupleurum on the electroencephalogram(EEG) and hippocampal slice by electroencephalograph and glass microelectrode extracellularly. Results: The seizure time and duration of each major seizure of epilepsy were significantly shortened and the interval of seizure significantly prolonged ( P <0.05)after intraabdominal injection of bupleurum root.After instilling the injection of bupleurum root onto the slices could reduce the amplitude of evoked field potential in epileptic hippocampal slices remarkably, the average of fall is 20.41% ,and restore in 6.86 minutes on average( P <0.001).Conclusion: Bupleurum root can inhibit the brain electrical activities in epileptic model, it is suggest that bupleurum has the distinct effect of antiepilepsy.

关 键 词：柴胡 癫痫模型 电活动 调制 脑电图 场电位 中药治疗 

分 类 号：R277.7[医药卫生—中医学]