TGF-β_1对胎儿晶状体上皮细胞增殖的作用
Action of TGFβ_1 to the proliferation in lens epithelial cells of human embryo</em>
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<p class='author'><strong>作 者：</strong><a href='/writer/article.aspx?id=100000008010517' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%ab%98%e7%a6%8f%e7%a6%84%5d' title='高福禄[1]'>高福禄[1]</a> <a href='/writer/article.aspx?id=100000004976034' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%89%9b%e5%97%a3%e4%ba%91%5d' title='牛嗣云[1]'>牛嗣云[1]</a> <a href='/writer/article.aspx?id=100000006482066' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%ba%9e%e5%b0%8f%e9%9d%99%5d' title='庞小静[1]'>庞小静[1]</a> <a href='/writer/article.aspx?id=100000002306426' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e6%98%a5%e8%89%b3%5d' title='王春艳[1]'>王春艳[1]</a> <a href='/writer/article.aspx?id=100000007867686' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%b5%b5%e8%89%b3%e8%8a%9d%5d' title='赵艳芝[1]'>赵艳芝[1]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=468&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%89%bf%e5%be%b7%e5%8c%bb%e5%ad%a6%e9%99%a2%e4%b8%ad%e5%bf%83%e5%ae%9e%e9%aa%8c%e5%ae%a4' title='[1]承德医学院中心实验室,河北省承德市067000'>[1]承德医学院中心实验室,河北省承德市067000</a> <em> </em></p><p class='from'><strong>出 处：</strong><a href='/journal/summary.aspx?gch=92134X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e7%9c%bc%e7%a7%91%e6%96%b0%e8%bf%9b%e5%b1%95%5d' title='眼科新进展'>《眼科新进展》</a>2002年第5期328-330,共3页<em>Recent Advances in Ophthalmology</em></p><p class='fund'><strong>基 金：</strong>河北省教育厅资助(编号:2000111)</p><p class='abstrack'><strong>摘 要：</strong> 目的 探讨转化生长因子-β1(transforminggrowthfactor-β1,TGF-β1)对胎儿晶状体上皮细胞增殖的作用。方法用 SP免疫组织化学法对 48例人胎儿不同胎龄晶状体上皮细胞进行细胞增殖核抗原 (proliferating cell nuclear anti-gen,PCNA)、TGF-β1免疫组织化学染色。结果 PCNA、TGF-β1在人胎儿不同胎龄晶状体上皮细胞均有表达 ;免疫阳性细胞随着胎龄的增加而减少。PCNA阳性细胞核为桔黄色或棕黄色 ;TGF-β1阳性细胞浆为桔黄色或棕黄色的颗粒状或斑块状 ;经相关分析 :TGF-β1与 PCNA呈正相关。结论 PCNA、TGF-β1在人胎儿不同胎龄晶状体上皮细胞均有表达 ;TGF-β1与 PCNA呈正相关 。<em><Abstrcat>ObjectiveTo observe the action of transforming growth factorβ1 (TGFβ1 ) to the proliferation in lens epithelial cells of human embryo. MethodsSP techniques were applied for immunohistochemical staining of lens epithelial cells (LECs) of 48 human embryos with proliferating cell nuclear antigen (PCNA)? TGFβ1 antibodies.ResultsWe found the expression of PCNA?TGFβ1 in LECs at different embryo age , the number of positive cells decreased with the increase of the embryo age. The positive staining for PCNA was orange or brown in the nucleus; the positive staining for TGFβ1 was orange or brown, and was scattered or mottled within the cytoplasm; Positive correlation had been found between TGFβ1 and PCNA by the relevant analysis. ConclusionThere are good expression of PCNA,TGFβ1 in LECs at different embryo age; Positive correlation had been found between TGFβ1 and PCNA, TGFβ1 can stimulate the proliferation of LECs of human embryo.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=4991510' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e6%99%b6%e7%8a%b6%e4%bd%93%e4%b8%8a%e7%9a%ae%e7%bb%86%e8%83%9e%5d' title='晶状体上皮细胞'>晶状体上皮细胞</a> <a href='/subject/article.aspx?id=4091953' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%bb%86%e8%83%9e%e5%a2%9e%e6%ae%96%e6%a0%b8%e6%8a%97%e5%8e%9f%5d' title='细胞增殖核抗原'>细胞增殖核抗原</a> <a href='/subject/article.aspx?id=3463095' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%bd%ac%e5%8c%96%e7%94%9f%e9%95%bf%e5%9b%a0%e5%ad%90-%ce%921%5d' title='转化生长因子-Β1'>转化生长因子-Β1</a> <a href='/subject/article.aspx?id=2492764' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%83%8e%e5%84%bf%5d' title='胎儿'>胎儿</a> <a href='/zk/search.aspx?key=K%3d%5b%e5%85%8d%e7%96%ab%e7%bb%84%e7%bb%87%e5%8c%96%e5%ad%a6%5d' title='免疫组织化学'>免疫组织化学</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR776' title='R776'>R776</a>[<a href = '/domain/article.aspx?id=507' >医药卫生—眼科</a>] </p>
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