轻度门脉高压的肝硬化患者心电图Q-Tc间期延长  

Prolonged Q-Tc interval in mild portal hypertensive cirrhosis

作　　者：Ytting H. Henriksen J.H. Fuglsang S. 程欣 

机构地区：[1]Department of Clinical Physiology and Nuclear Medicine 239, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第1期59-59,共1页Core Journals in Gastroenterology

摘　　要：Background/Aims: The Q-Tc interval is prolonged in a substantial fraction of patients with cirrhosis, thus indicating delayed repolarisation. However, no information is available in mild portal hypertensive patients. We therefore determined the Q-Tc interval in cirrhotic patients with hepatic venous pressure gradient (HVPG) < 12 mmHg. Methods: Forty-four patients with cirrhosis and HVPG < 12 mmHg underwent a haemodynamic study. They were compared with 36 cirrhotic patients with clinically significant portal hypertension (HVPG ≥ 12 mmHg) and controls without liver disease. Results: The fraction with prolonged Q-Tc interval ( > 0.440 s1/2) was similar in the two cirrhotic groups (49 vs 50% , ns) and significantly above that of the controls (5% , P < 0.005). Q-Tc was normal in patients with normal HVPG. Likewise, mean Q-Tc was 0.449 and 0.447 s1/2 in the two cirrhotic groups (ns), values which are significantly above that of the controls (0.410 s1/2, P < 0.01). In the mild portal hypertensive group, the Q-Tc interval was inversely related to indicators of liver function, such as indocyanine green clearance (r = -0.34, P < 0.02). Conclusions: Delayed repolarisation of the myocardium already occurs in a substantial fraction of patients with cirrhosis with only a mild increase in portal pressure. The prolonged Q-Tc interval may be related to liver dysfunction and to the presence of portal hypertension.Background/Aims: The Q-Tc interval is prolonged in a substantial fraction of patients with cirrhosis, thus indicating delayed repolarisation. However, no information is available in mild portal hypertensive patients. We therefore determined the Q-Tc interval in cirrhotic patients with hepatic venous pressure gradient (HVPG) < 12 mmHg. Methods: Forty-four patients with cirrhosis and HVPG < 12 mmHg underwent a haemodynamic study. They were compared with 36 cirrhotic patients with clinically significant portal hypertension (HVPG ≥ 12 mmHg) and controls without liver disease. Results: The fraction with prolonged Q-Tc interval ( > 0.440 s1/2) was similar in the two cirrhotic groups (49 vs 50% , ns) and significantly above that of the controls (5% , P < 0.005). Q-Tc was normal in patients with normal HVPG. Likewise, mean Q-Tc was 0.449 and 0.447 s1/2 in the two cirrhotic groups (ns), values which are significantly above that of the controls (0.410 s1/2, P < 0.01). In the mild portal hypertensive group, the Q-Tc interval was inversely related to indicators of liver function, such as indocyanine green clearance (r = -0.34, P < 0.02). Conclusions: Delayed repolarisation of the myocardium already occurs in a substantial fraction of patients with cirrhosis with only a mild increase in portal pressure. The prolonged Q-Tc interval may be related to liver dysfunction and to the presence of portal hypertension.

关 键 词：Q-TC间期 门脉高压 肝静脉压力梯度 肝脏疾病 心肌复极 血流动力学 靛氰绿 清除率 样地 负相关 

分 类 号：R575.2[医药卫生—消化系统]