肝素壳多糖缓释剂预防后发性白内障的研究  

Study on the prevention of posterior capsular opacification by heparin-chitin drug delivery system

作　　者：蒋炎云[1] 蒋珍新[2] 戴莉[2] 邹尉玉[1] 赵长松[1] 

机构地区：[1]华中科技大学同济医学院眼科,武汉430030 [2]江汉油田中心医院

出　　处：《眼科研究》2002年第5期404-406,共3页Chinese Ophthalmic Research

摘　　要：目的　通过观察肝素壳多糖缓释剂置入兔眼白内障囊外摘出术 (ECCE)后的后囊膜的病理变化 ,探讨其对后发性白内障发生的预防效果。方法　青紫蓝兔 2 4只共 48眼随机分 4组 ,建立白内障动物模型 ,在ECCE中分别应用缓冲液 (PBS)、2 0 0U/ml肝素、2 %壳多糖、2 0 0U/ml肝素壳多糖缓释剂 0 1ml注入囊袋内 ,术后不同时间应用裂隙灯显微镜、光镜观察角膜、前房及晶状体后囊膜等眼部组织的变化。结果　肝素壳多糖组后囊膜偶见细胞生长 ,后囊膜光滑。肝素壳多糖组与其他 3组的后囊膜混浊率有显著性差异 (P <0 0 5 )。结论　肝素壳多糖缓释剂能有效地预防后发性白内障的发生。ObjectiveTo investigate the preventive effect of heparin-chitin drug deliver system on posterior capsular opacification.Methods24 adult pigmented rabbits(48 eyes)were randomly divided into 4 groups.Phosphate buffer saline(PBS),200 U/ml heparin,chitin and heparin-chitin drug deliver system were injected into the capsular bag of 48 rabbit eyes during extracapsular cataract extraction(ECCE)in different groups,respectively.The changes of lens posterior capsula and intraocular tissue were observed by slit-lamp microscope and light microscope at different intervals after operation.ResultsThere was few cells on the posterior capsula in heparin-chitin drug deliver system group.A significant difference was found in the rate of posterior capsular opacification between heparin-chitin drug deliver system group and others (P<0.05).ConclusionHeparin-chitin drug deliver system can prevent the development of posterior capsular opacification more effectively.

关 键 词：预防 肝素 壳多糖 缓释剂 后发性白内障 白内障摘除术 术后并发症 

分 类 号：R776.1[医药卫生—眼科] R779.66[医药卫生—临床医学]