前程加速放射治疗食管癌临床观察  

Result of early course accelerated radiotherapy for esophageal carcinoma

作　　者：乔田奎[1] 张桂兰[1] 李岳山[2] 辛立[1] 刘海燕[1] 常军[1] 

机构地区：[1]泰山医学院附属医院肿瘤科,山东泰安271000 [2]新泰市人民医院

出　　处：《中国肿瘤临床与康复》2002年第5期101-102,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的　评价前程加速放射治疗食管癌的疗效。方法　自 1994年 1月至 1996年 2月 ,选择 10 6例食管癌患者 ,随机分为两组 :(1)前程加速放射治疗组 5 3例 ,放射治疗第 1,2周 ,每天 3Gy ,5次 /周 ,第 3 ,4周 ,每天 2Gy ,5次 /周 ,总剂量 5 0Gy/ 4周 ;(2 )常规放射治疗组 5 3例 ,每天 2Gy ,5次 /周 ,总剂量 60Gy/ 6周。 结果　前程加速组 5年局部控制率和 5年生存率明显高于常规放疗组 ,分别为 41.5 %比 18.9%和 18.7%比 9.7% ,放疗副作用两组无明显差别。结论　结果显示前程加速放射治疗能提高食管癌局部控制率和生存率。ObjectiveTo evauate the efficacy of early course accelerated radiotherapy for esophageal carcinoma.MethodsFrom Jan.1994 to May 1995,106 patients with esophageal carcinoma were radomized into two groups:The early course accelarated group received accelerated radiotherapy(3 Gy per day,5 times a week )during the early two weeks of the course of radiotherapy,followed by conventional fractionation radiotherapy during the late two weeks.The conventional fractionation group received routine radiotherapy(2 Gy per day,5 times a week,total dose of 60 Gy in weeks).ResultsThe local tumor control rates and the 5-year survival rates in the early course accelerated radiotherapy were higher than those of the conventional radiotherapy group,being respectively 41.5% vs 18.9% and 18.7% vs 9.7%.There was no significant difference between the two groups in radiotherapy symptoms.ConclusionThe preliminary results showed that the early course accelarated radiotherapy for esophageal carcinoma can give higher survival rate and local tumor control rate.

关 键 词：前程加速 放射治疗 食管癌 临床观察 

分 类 号：R735.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]