介入化疗对直肠癌血管内皮生长因子及微血管的影响  

Effect of chemotherapy on vascular endothelial growth factor expression and microvessel density in rectum carcinoma

作　　者：丁瑞亮[1] 王炳胜[1] 刘秀芳[1] 赵增虎[1] 李成云[1] 王涛[1] 张海[1] 

机构地区：[1]解放军251医院肿瘤科,河北张家口075000

出　　处：《中国肿瘤临床与康复》2002年第5期46-47,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的　探讨介入化疗对直肠癌血管内皮生长因子表达 (VEGF)及微血管计数 (MVD)的影响。方法　对 3 4例直肠癌患者介入化疗前后的肿瘤组织 ,用CD3 4对VEGF表达进行测定 ,并进行MVD计数。结果　本组患者介入化疗前及后 4至 5周VEGF阳性表达率分别为 61.7% (2 1/3 4)、3 2 .4% (11/3 4) ,MVD计数明显降低 ,差异均有显著性意义(P <0 .0 1)。结论　介入化疗能降低直肠癌组织VEGF的表达 ,减少MVD计数 ,提示介入化疗可能调节直肠癌的分化程度 ,减少术后转移。ObjectiveTo evaluate the effect of chemotherapy on vascular endothelial growth factor (VEGF) expression and microvessel density(MVD) in rectum carcinoma.MethodsBefore chemotherapy and after 4～5 weeks of therapy,the expression of VEGF and MVD count in 34 carcinoma tissues of rectum cancer were determined by CD34.ResultsBefore chemotherapy and after 4～5 weeks,the expression of VEGF were 61.7%(21/34) and 32.4%(11/34) respectively,and MVD were reduced obviously (P<0.01).ConclusionThe intervention chemotherapy can reduce the expression of VEGF, decrease MVD,adjust malignancy of rectum carcinoma,and cut down the postoperative metastasis.

关 键 词：介入化疗 直肠癌 血管内皮生长因子 微血管密度计数 肿瘤转移 

分 类 号：R735.37[医药卫生—肿瘤]