肺癌化疗前后外周血端粒酶活性的变化及临床意义  

Peripheral blood telomerase activity in lung cancer patients before and after chemotherapy

作　　者：冯光丽[1] 冯久贤[2] 赵家美[1] 杨新法[1] 

机构地区：[1]上海市胸科医院肺内科,上海200030 [2]上海市胸科医院胸部肿瘤研究所

出　　处：《肿瘤》2002年第5期417-418,共2页Tumor

摘　　要：目的　评价测定外周血中端粒酶活性在肺癌化疗中的临床价值。方法　采用端粒酶重复序列扩增和微板杂交检测方法 ,检测 4 9例肺癌患者化疗前后外周血中端粒酶活性并进行分析和评价。结果　化疗前后端粒酶活性变化与病理类型有关 ,小细胞肺癌化疗后全部下降。 31例化疗后端粒酶活性下降 ,其中 2 1例化疗达有效。而 18例端粒酶活性升高中化疗无效占15例。结论　测定肺癌患者化疗前后外周血中的端粒酶活性变化对肺癌化疗疗效的评定有比较重要的意义。Objective To evaluate the clinical significance of peripheral blood telomerase activity in lung cancer after chemothenapy. Methods The telomerase activity in peripheral blood was measured by TRAP-ELISA in 49 patients with lung cancer before and after chemotherapy. Its relationship with response was analyzed. Results The change of telomerase activity before and after chemotherapy was dependent on the histology of lung cancer, especially in patients with small cell lung cancer. In 31 patients whose activity was decreased after chemotherapy, 21 cases had response. In contrast, 15 of 18 patients with increased activity after chemotherapy showed no response. Conclusion The change of telomerase activity after chemotherapy appears to be an indicator for response in lung cancer.

关 键 词：化学疗法 肺癌 外周血 端粒酶活性 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]