胃癌组织中Ⅳ型胶原的表达意义及相关性研究  

Significance of expression and correlative study of collagen type Ⅳ content in gastric cancer tissue

作　　者：邓跃华[1] 刘功传[1] 刘弋[1] 韩涵[1] 

机构地区：[1]安徽医科大学第一附属医院,合肥230022

出　　处：《肿瘤》2002年第5期419-420,共2页Tumor

摘　　要：目的　探讨胃癌组织中Ⅳ型胶原 (IV C )含量变化与胃癌患者血清含量的相关性及临床意义。方法　应用放射免疫技术测定 2 1例胃癌患者胃切除标本组织和血清中IV C的含量以及 2 0例健康者 (对照组 )血清IV C含量。结果　胃癌患者血清中IV C含量明显高于对照组 (P <0 .0 5 ) ;胃癌组织中IV C含量明显高于 6cm以远的正常胃组织 (P <0 .0 5 ) ;胃癌组织与血清中IV C含量升高呈正相关 (P <0 .0 5 )。结论　胃癌组织中不同部位的IV C含量变化与胃癌患者血清中IV C含量及胃癌细胞的生物学活性密切相关 ,动态观察血清IV C含量对判断胃癌病情、预后及手术根治效果具有一定的参考价值。Objective To evaluate the clinical significance and correlation of gastric carcinoma tissue and serum collagen type IV (IV-C) content in patients with gastric cancer. Methods Gastric sample tissue and serum content of IV-C in 21 patients with gastric cancer were measured by radioimmunoassay. Results The content of IV-C in cancer group was significantly higher than those in control group ( P <0.05). The content of IV-C in gastric cancer tissue was higher than those in normal gastric tissue ( P <0.05). The elevation of IV-C contents in gastric carcinoma tissue and serum was positively correlative ( P <0.05). Conclusion In patients with gastric cancer, the IV-C contents in different loci of gastric tissue and in serum content are closely related to tumor biological property, and that successive detection of IV-C serum content could be a simple and useful test for judging the patient's condition and the prognosis of gastric cancer.

关 键 词：胃癌 Ⅳ型胶原 放射免疫法 临床意义 血清 肿瘤生物学 

分 类 号：R735.2[医药卫生—肿瘤]