左旋四氢巴马汀对大鼠和小鼠脑缺血再灌注损伤的保护作用  

PROTECTIVE EFFECT OF L-TETRAHYDROPALMATINE AGAINST CEREBRAL ISCHEMIA-REPERFUSION INJURIES IN RATS AND MICE

作　　者：刘家兰[1] 李德清[1] 

机构地区：[1]湖北民族学院医学院药理教研室,恩施445000

出　　处：《中国现代医学杂志》2002年第18期48-50,共3页China Journal of Modern Medicine

摘　　要：目的 :观察左旋四氛巴马汀 (THP)对脑缺血再灌注损伤的保护作用 ;方法 :采用大鼠和小鼠脑缺血再灌注模型。结果 :在大鼠和小鼠脑缺血再灌注模型上 ,THP30 ,6 0mg/kg ,iv及 6 0 ,12 0mg/kgiv ,可显著提高下脑组织乳酸脱氢酶 (LDH)及超氧化物歧化酶 (SOD)活性、明显降低丙二醛 (MDA)含量。在大鼠局灶性脑缺血 2h再灌注 2 4h模型上 ,THP30 ,6 0mg/kg ,iv可明显缩小梗死灶面积 ,并显著抑制脑缺血组织中LDH和SOD活性降低 ,减少MDA过量生成。结论 :THP对大鼠和小鼠脑缺血再灌注损伤有显著保护作用。Objective:To determine the protective effect of L-tetrahydropalmatine against cerebral ischemia-reperfusion injuries.Methods: The effects of sal on lactic debydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyde (MDA) of cerebral ischemia-reperfusion injured mouse and rat models were observed .Results:THP 30,60mg/kg and 60, 120mg/kg iv could markedly increase the activities of LDH and SOD and lower the production of MDA in the injured cerebral tissue. On focal cerebral ischemia reperfusion injured rat,24h reperfusion after 2h ischemic injury,30,60mg/kg iv THP could decrease infarct size, ameliorate neurological deficit with obvious inhibition of the decrease of LDH and SOD activities and the over production of MDA .Conclusions:THP shows obvious protective effects on cerebral ischemia reperfusion injuries of rats and mice via attenuating oxygen free radical.

关 键 词：脑缺血 再灌注损伤 左旋四氢巴马汀 乳酸脱氢酶 氧自由基 动物实验 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R965[医药卫生—临床医学]