亚低温治疗急性脑血管病的临床及实验室研究  

Clinical and laboratory study of moderate hypothermia on treating acute cerebrovascular disease.

作　　者：田国萍 吴丽华[1] 王静娥[1] 朱春艳[1] 徐冰[1] 

机构地区：[1]沈阳市第一人民医院,110041

出　　处：《中国实用内科杂志》2002年第10期601-602,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的　探讨亚低温对急性脑血管病的治疗作用机制及最佳治疗时机。方法　采用“TY -98系列微机控制颅脑降温仪” ,对 82例脑损伤患者观察亚低温治疗前后及亚低温治疗组与对照组的临床疗效及实验室指标。结果　亚低温治疗前后及亚低温治疗组与对照组比较神经功能明显改善 ,体温、NO、ICAM -1及IL -1明显降低 ,SOD增加。生存率及恢复良好率治疗组与对照组比较明显提高。最佳治疗时机在发病 2h以内。结论　亚低温治疗能有效提高脑损伤治愈率 。Objective To demonstrate the moderate hypothermia's effect to acute cerebrovascular disease.Methods 82 prospective patients with acute cerebrovascular disease treated by moderate hypothermia were evaluated.According to the standard of clinical neurologic deficiency ,we contrasted the clinical and laboratory effect of control before moderate hypothermia and after moderate hypothermia. Results The neurologic function and SOD improved obviously; NO,ICAM-1,IL-1 and temperature decreased after moderate hypothermic therapy;patients'survival rate and recovery rate improved obviously too.The best therapy time was within 2h after acute cerebrevascular disease happened. Conclusions Moderate hypothermia can improve heal rate of brain damage and decrease mortality and disable rate.

关 键 词：亚低温 治疗 急性脑血管病 实验室研究 自由基 炎症反应 

分 类 号：R743.305[医药卫生—神经病学与精神病学]