利用基因敲除小鼠研究发热机制的进展  

Progress in studying the mechanism of fever using knockout mice

作　　者：李沧海[1] 霍海如[1] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国病理生理杂志》2002年第9期1151-1156,共6页Chinese Journal of Pathophysiology

基　　金："九五"国家攀登计划预选项目资助(No.970 2 110 18)

摘　　要：Increasing evidence suggests that a complex net-work of fever induction pathways in mammalian exists. In this article,the overview of recent studies on the mechanism of fever induced by different pyrogens using IL-1, IL-1R, ICE, IL-1ra, IL-1RacP, IL-6,IL-10,TNFR,cPLA 2,COX,EP,AT 2,iNOS and D 2/3 knockout mice is presented. Hyperthermia respond to localized infection/inflammation(e.g.,sc injection of turpentine) is mediated by IL-1β and IL-6 in turn.While fever induced by systemic infection/inflammation(e.g.,treatment with LPS intraperitoneally) varies with the different doses of pyrogens administered .Fever caused by a low dose of LPS administered ip is IL-6 dependent ,but the IL-6 independent pathway is crucial for the fever evoked by a high dose of LPS.Febrile responses during both local and systemic infection/inflammation develop totally through central PGE 2 dependent mechanism, but some stress induced hyperthermia otherwise.Increasing evidence suggests that a complex net-work of fever induction pathways in mammalian exists. In this article,the overview of recent studies on the mechanism of fever induced by different pyrogens using IL-1, IL-1R, ICE, IL-1ra, IL-1RacP, IL-6,IL-10,TNFR,cPLA 2,COX,EP,AT 2,iNOS and D 2/3 knockout mice is presented. Hyperthermia respond to localized infection/inflammation(e.g.,sc injection of turpentine) is mediated by IL-1β and IL-6 in turn.While fever induced by systemic infection/inflammation(e.g.,treatment with LPS intraperitoneally) varies with the different doses of pyrogens administered .Fever caused by a low dose of LPS administered ip is IL-6 dependent ,but the IL-6 independent pathway is crucial for the fever evoked by a high dose of LPS.Febrile responses during both local and systemic infection/inflammation develop totally through central PGE 2 dependent mechanism, but some stress induced hyperthermia otherwise.

关 键 词：小鼠 基因敲除 发热 细胞活素类 前列腺素类 

分 类 号：R364.6[医药卫生—病理学]