端粒酶基因hTRT在甲状腺乳头状癌的表达及意义  

Expression of Telomerase Gene hTRT and its Significance in Thyroid Papillary Carcinoma

作　　者：黄雄飞[1] 张鹏飞[1] 高凌云[1] 高美钦[1] 郑朝增 

机构地区：[1]福建医科大学基础医学院病理系,福州350004 [2]福建省德化县中医院病理科,德化362500

出　　处：《福建医科大学学报》2002年第3期254-256,F002,共4页Journal of Fujian Medical University

基　　金：福建省教育厅科研基金资助项目 (JA0 0 199)

摘　　要：目的　探讨端粒酶基因 h TRT在甲状腺乳头状癌的表达及其意义。　方法　应用原位杂交方法检测端粒酶基因 h TRT在 30例甲状腺乳头状癌、19例甲状腺良性病变及 16例癌旁正常甲状腺组织中的表达。　结果　 h TRTm RNA在甲状腺乳头状癌中的阳性率为 (2 5 /30 ,83.3% ) ,显著高于甲状腺良性病变中的阳性率 (3/19,15 .8% )和正常甲状腺组织中的阳性率 (0 /16 ,0 % ) ;而且病期晚及有淋巴结转移者阳性率增高。　结论　端粒酶基因 h TRT为甲状腺乳头状癌恶性表型增高的标志。 h TRTmObjective\ To study telomerase gene hTRT expression and its significance in papillary thyroid carcinoma(PTC).\ Methods\ 30 PTC, 19 thyroid benign leisions and 16 normal thyroid tissues were examined by in situ hybridization for hTRT mRNA expression.\ Results\ Positive rate of hTRT mRNA expression in PTC(83.3%) was significantly higher in comparision to that in benign thyroid disease(15.8%) and in normal thyroid tissues(0%).\ Patients with poor phenotype of PTC or with lymph node metastases showed statistically significant higher positive rate.\ Conclusion\ Telomerase gene hTRT mRNA is a marker of poor magnificent phenotype of PTC, it may be helpful to the diagnosis and prognostic valuation of PTC.\;

关 键 词：端粒酶 甲状腺乳头状癌 基因表达 HTRT基因 原位杂交 辅助诊断 预后 

分 类 号：R736.1[医药卫生—肿瘤]