癫痫病人大脑皮质GR和mGLUR1的免疫反应性变化  

IMMUNOREACTIVITY CHANGES OF GR AND mGLUR1 IN THE CEREBRAL CORTEX IN EPILEPTIC PATIENTS

作　　者：宋秀祖[1] 朱家祥[1] 刘庆莹[1] 朱长庚[1] 魏瑛[1] 童逸龄[1] 熊密[2] 

机构地区：[1]华中科技大学同济医学院解剖学教研室脑研究室,武汉430030 [2]华中科技大学同济医学院病理学教研室

出　　处：《解剖学报》2002年第5期463-465,共3页Acta Anatomica Sinica

基　　金：国家自然科学基金重点项目资助课题 (3 93 3 0 2 10 )

摘　　要：目的　探讨癫痫的发病机制。　方法　应用免疫细胞化学方法 ,分别研究癫痫病人病灶区手术切除标本和正常标本代谢性谷氨酸受体 1(mGLUR1)和糖皮质激素受体 (GR)免疫反应性的变化 ,并做显微图像分析。　结果　与正常标本对比 ,癫痫病人mGLUR1阳性细胞数量明显增加 ,平均光密度值增加 ,而GR阳性细胞数量则减少 ,平均光密度也减少。统计学分析表明差异有显著性 (P <0 0 5 )。Objective To explore the mechanism of epilepsy. Methods Immunoreactive changes of GR and mGLUR1 were observed in epileptic patients compared with that of normal human brain tissue by immunocytochemistry.The image analysis was used in this experiment as well. Results The mGLUR1 positive cells and their average optical density were obviously increased in the epileptic focuses,while the GR positive cells were decreased compared with that of the normal human brain tissue.The difference was significant in statistics( P <0\^05).Conclusions\ GR and mGLUR1 may have close relationship with epileptiform.

关 键 词：大脑皮质 免疫反应性 癫痫 糖皮质激素受体 代谢性谷氨酸受体 发病机制 免疫细胞化学 

分 类 号：R742.1[医药卫生—神经病学与精神病学]