谷氨酸单钠对大鼠胃肠粘膜5-羟色胺表达的影响  

THE EFFECT OF MSG ON THE EXPRESSION OF 5-HT IN GASTROENTERIC MUCOSA OF RAT

作　　者：季凤清[1] 尚宏伟[2] 王兴翠[2] 郭崇洁[1] 

机构地区：[1]首都医科大学组织学胚胎学教研室,北京100054 [2]首都医科大学实验中心,北京100054

出　　处：《解剖学报》2002年第5期542-545,共4页Acta Anatomica Sinica

摘　　要：目的　探讨谷氨酸单钠对大鼠胃肠粘膜五羟色胺 (5 HT)表达的影响。　方法　采用免疫组织化学技术检测胃肠粘膜 5 羟色胺的表达并用图象分析系统进行定量。　结果　谷氨酸单钠可使胃肠粘膜 5 羟色胺表达增强 ,以 12 0d(成年期 )最为明显 ,5 2d(青春期 )次之 ,各组与对照组比具有显著性差异P <0 0 1。　结论　谷氨酸单钠可使胃肠粘膜 5 羟色胺表达增强 ,这可能是MSG导致神经内分泌紊乱的机制之一。Objective To explore the effect of monosodium glutamate (MSG) on the expression of 5\|HT in gastroenteric mucosa of rat. Methods Immunohistochemical technique was used to detect the expression of 5\|HT. The immuno\|activity and the density of positive cells were measured by image analysis. Results The immuno\|activity and the density of 5\|HT positive cells(EC cell) in the experimental group are higher than that in control group. The effect by 120d is the most significant, followed by that of 52d. Statistical analysis showed a significant difference ( P< 0\^01).Conclusion MSG could increase the expression of 5\|HT in gastroenteric mucosa. This may be one of the mechanisms of neuroendocrine disorder induced by MSG.

关 键 词：谷氨酸单钠 胃肠粘膜 五羟色胺 免疫组织化学 大鼠 神经毒性 

分 类 号：R965[医药卫生—药理学]