含有1H-1,2,4-三唑咪唑[2,1-b]-1,3,4-噻二唑、S-三唑[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性  

Synthesis and Biological Activities of Imidazolo[2,1-b]-1,3,4-thiadiazole,S-Triazole[3,4-b]-1,3,4-thiadiazole Derivatives Bearing 1H-1,2,4-triazole

作　　者：张艳[1] 刘东[1] 戴朝峰[1] 张自义[1] 许鹏飞[1] 惠新平[1] 王勤[2] 

机构地区：[1]兰州大学化学化工学院 [2]兰州大学生命科学学院,兰州730000

出　　处：《高等学校化学学报》2002年第10期1882-1886,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :QT Program)资助

摘　　要：合成了 1 8个含有 1 H-1 ,2 ,4-三唑的咪唑 [2 ,1 -b]-1 ,3 ,4-噻二唑以及 S-三唑 [3 ,4-b]-1 ,3 ,4-噻二唑的稠杂环衍生物 ,经元素分析及谱学表征 ,探讨 2 ,5 ,6-三取代咪唑 [2 ,1 -b]-1 ,3 ,4-噻二唑的可能生成机制 .对大肠杆菌、绿脓杆菌、枯草杆菌等初步抑菌试验证明 。Eighteen novel imidazolo-1,3,4-thiadiazoles and S-triazole-1,3,4-thiadiazoles containing 1H-1,2,4-triazole were synthesized and their structures were confirmed by elemental analyses and spectral analysis. And the characteristic data of 1H NMR and MS were explained reasonably. Furthermore, we also proposed the synthetic mechanism of 2,5,6-substituted-imidazolo-1,3,4-thiadiazole. Primary antibacterial test against E.coli, P.aeruginosa, B.subtilis and S.aureus showed that most of them had good antibacterial activities.

关 键 词：合成 生物活性 1H-1 2 4-三唑 咪唑[2 1-b]-1 3 4-噻二唑 S-三唑[3 4-b]-1 3 4-噻二唑 抑菌活性 

分 类 号：O626.2[理学—有机化学]