肾病综合征患儿治疗过程中激素不良反应的临床观察  

A Clinical Observation on Side Effect of Glucocorticoid on Nephrotic Syndrome in Children

作　　者：胡小娟[1] 邓颖[1] 翁志媛[1] 于力[1] 卓美瑛[1] 

机构地区：[1]广州市第一人民医院儿科,510180

出　　处：《医学理论与实践》2002年第10期1134-1135,共2页The Journal of Medical Theory and Practice

摘　　要：目的:本文探讨小儿原发性肾病综合征(INS)应用精皮质激素治疗过程中不良反应的早发现、早防治的临床意义。方法:回顾性分析60例INS患儿采用口服强的松治疗过程中发生的不良反应。结果:INS应用糖皮质激素治疗过程中发生不良反应81例次,其中包括感染性疾病47例(58.0％),电解质紊乱13例(16.0％),高凝状态6例(7.4％),高血压脑病5例(6.2％),肾上腺皮质功能不全3例(3.7％),消化道出血3例(3.7％)。结论:激素治疗小儿INS使不少患儿得到缓解,但也产生不少不良反应,对此应该重视对INS应用糖皮质激素治疗过程中出现不良反应的早发现、早防治,以提高激素治疗效果。Objective: To observe the side effect of hormone on nephrotic syndrome (NS) in children. Method : 60 hospitalized cases of NS which took prednisone orally were investigated . Results : side effect occured 81 cases - times, including 47 cases of infectious diseases (58.0%),13 cases of disorder of electrolyte (16.0%),6 cases of hypercoagulability (7.4%), 5 of hypenensive encephalophathy ( 6.2 % ) , 3 of Addison disease( 3.7 % ) , 3 of gastrointestinal haemorrage (3.7%). Conclusion : Side effect of hormone therapy of NS in children is not unusual . In order to improve the level of managing hormone it is important to find and prevent the side effect early.

关 键 词：肾病综合征 糖皮质激素 不良反应 儿童 INS 

分 类 号：R726.92[医药卫生—儿科] R977.1[医药卫生—临床医学]