HAB/DBP复合物修复骨缺损的实验研究  

Restoration of radii defects with HAB/DBP composite in rabbits

作　　者：刘峰[1] 唐立辉[1] 吴军正[1] 

机构地区：[1]西安第四军医大学口腔医学院,710032

出　　处：《实用口腔医学杂志》2002年第5期415-417,共3页Journal of Practical Stomatology

摘　　要：目的 :研究羟基磷灰石人工骨 (HAB) /异体脱矿骨粉 (DBP)复合物修复骨缺损的效果 ,以期获得一种既具有传导性又具有骨诱导性的复合材料。方法 :将HAB/DBP复合物、HAB、异体脱矿骨 (DMB)植入兔桡骨中段骨缺损处 ,设置空白对照 ,在 2、4、8、12周分别取材 ,观察新骨形成及骨缺损修复情况。结果 :HAB/DBP组、DMB组 2周时可见骨断端附近有大量软骨细胞聚集 ,并有少量基质形成。 4周时 ,大量软骨细胞及少量骨小梁。 8周时 ,见大量骨小梁和层板状骨形成。 12周见层板状成熟骨组织和哈佛系统形成。其成骨能力及新骨生成量明显高于HAB组及空白组。结论 :HAB/DBP复合物为一种既具有骨传导性又具有骨诱导性的骨缺损修复材料 ,具有与DMB同样的诱导骨生成的能力 。Objective: The purpose of this study is to investigatc the effects of the HAB/DBP composite in the restoration of restoring bone defects. Methods: The HAB/DBP composiite, HAB or DMB samples were grafted into the defects of rabbit's radii respectively and the samples were examined 2 weeks, 4 weeks, 8 weeks and 12 weeks after operation with general, radiological and histological observations respectively.Results: In the group of HAB/DBP composssite implanted area , mesenchymal cells and new bone stromas were observed assembling 2 weeks after the operation. New bone formation and bone trabeculation were found 4 weeks after transplantation. A lot of bone trabeculation and composite degrad ation were observed 8 weeks after operation. The defects were completely restored 12 weeks after the surgery.Conclusion: The HAB/DBP composite has the properties of osteoconduction and osteoinduction, and its osteogenic ability is similar to that of DMB.

关 键 词：HAB/DBP复合物 修复 骨缺损 实验研究 羟基磷灰石类 人工骨 脱矿骨 

分 类 号：R782[医药卫生—口腔医学]