急性髓性白血病免疫球蛋白重链重因和T细胞受体γ基因重排的检测及意义  

Significance of detecting the clonal rearrangement of immunoglobulin heavy chain gene and T cell receptor γ gene in patients with acute myeloid leukemia

作　　者：许莲蓉[1] 乔振华[1] 苏丽萍[1] 马梁明[1] 王宏伟[1] 张丽[1] 朱镭[1] 

机构地区：[1]山西医科大学第二临床医学院血液内科,太原030001

出　　处：《山西医科大学学报》2002年第5期406-408,共3页Journal of Shanxi Medical University

摘　　要：为检测急性髓性白血病 (AML)患者免疫球蛋白重链基因 (IgH)和T细胞受体γ基因 (TCRγ)克隆性重排情况 ,并初步探讨其意义 ,采用聚合酶链反应 (PCR)检测 51例AML患者IgH及TCRγ基因重排。结果表明 ,51例患者中 9例 (1 7.65 % )发生IgH基因重排 ,1 1例 (2 1 .57% )出现TCRγ基因重排。由此可见 ,AML中确实存在系列失真现象 。To investigate the clonal rearrangement of immunoglobulin heavy chain (IgH) and T cell receptor (TCR) γ genes in patients with acute myeloid leukemia and their significance, polymerase chain reaction(PCR) was used to study IgH and TCRγ genes rearrangement in 51 patients with acute myeloid leukemia. The result showed that IgH gene rearrangement was found in 9 patients and TCRγ gene rearrangement in 11 patients. It suggests that there will be the lineage infidelity, not only IgH gene but also TCRγ gene rearrangement, in AML.

关 键 词：急性髓性白血病 免疫球蛋白重链 T细胞受体 Γ基因重排 检测 

分 类 号：R733.71[医药卫生—肿瘤]