心房颤动的家谱分析  

Analysis of familial atrial fibrillation

作　　者：任建英[1] 王瑛[1] 章之川[1] 徐伟民[1] 余琛[1] 

机构地区：[1]上海市徐汇区中心医院,上海200031

出　　处：《心血管康复医学杂志》2002年第5期397-398,404,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：上海市卫生局基金资助项目(编号982006).

摘　　要：目的:探讨心房颤动发病的遗传性。方法:对13例心房颤动进行家谱调查,每个家谱进行3～4代人调查,调查包括对房颤患者进行心电图、心动超声图等一系列检查,其中一部分家庭成员采血进行了DNA分析。结果:本组房颤均于40岁以后（年龄45～81岁）发病,房颤包括持续性与阵发性房颤.除1例外,男性房颤均有10年以上的吸烟史,第1家谱中;第二代有4例房颤患者.第8、10个家谱中第二代分别各有3例房颤。结论:本组房颤均于成年发病,房颤病例见于2～3代发病,推测部分房颤的发病病因与基因有关,尚待进一步扩大病例深入研究。Objective:To study the heredity of atrial fibrillation. Methods:Thirteen series of family members with atrial fibrillation including 3^-4 generations were survey. Blood samples of some patients were collected for DNA analysis. Results: There were 39 patients with atrial fibrillation (without organic cardiopathy) in 13 series of family memyers with atrial fibrillation, in which 27 patients with atrial fibrillation survived, their atrial fibrillation oCCUrred after the age of 40 years (age ranged from 45 to 81 years old). Atrial fibrillation including persistent or paroxysmal was observed. In 2 nd generation of 1, 8, 10 series of family members with atrial fibrillation, there were 4, 3, 3 patients with atrial fibrillation respectively. Conclusion: Part of familial atrial fibrillation is related with gene. Further study should be carried out in more.

关 键 词：心房颤动 家谱调查 DNA 遗传性 

分 类 号：R541.75[医药卫生—心血管疾病]