含铬鱼肉质遗传毒理学检测与评价  

Preliminary Evaluation of Genetic Toxicology of Meat from Common Carp Exposed to Chromium

作　　者：邱隽[1] 王小雪[1] 魏东魁 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150001 [2]哈尔滨市香坊区卫生防疫站

出　　处：《中国公共卫生》2002年第10期1209-1210,共2页Chinese Journal of Public Health

摘　　要：目的　探讨含铬鱼可食性及铬的毒理学特性。方法　以氯化铬 0 5mg/Cr/kg饵料喂饲鲤鱼 2个月 ,以全鱼为受试物 ,不同剂量给小鼠一次灌胃 ,观察 2周。结果　急性毒性实验证明该样品为无毒物质。遗传毒理学检测 ,小鼠骨髓嗜多染微核试验阴性 ;小鼠睾丸染色体畸变分析未见染色体损伤 ;小鼠伤寒沙门氏菌 /微粒体试验 (Ames)在不加与加S9代谢活化系统的条件下 ,对Ames试验菌株均呈阴性结果。结论　铬对鱼无致突变作用 。Objective To dicuss the edibility of fish with Cr and toxicological characteristic of Cr.Methods Minced whole fish(Cyprinus carpio)fed with the diet containing 0\^5mgCr/kg for 2 months was used for genetic toxicological test.The minced meat was administered at various doses to mice by stomach tube and mice were observed for two weeks.Results Acute toxicological test showed that minced fish meat was intoxic.Test of micronuclealus in red cells of bone marrow was negative.No chromosome damages were found in chromosome mutagenic analysis.Ames test was also negative in either with or without adding S\-9 metabolic simulating system.Conclusion Minced Cr containing fish meat had no mutagenic effect and was safe from the point of genetic toxicologicy.

关 键 词：铬 鱼 遗传毒理学 评价 

分 类 号：R155.55[医药卫生—营养与食品卫生学]