原发性中枢神经系统淋巴瘤六例报告  

Report of Primary Central Nervous System Lymphoma with Six Cases

作　　者：钱海蓉[1] 戚晓昆[1] 冯大刚[1] 刘锦宏 冯涛[1] 刘鹏[1] 

机构地区：[1]海军总医院神经内科,北京100037 [2]湖北省荆州市结核病院,湖北荆州414100

出　　处：《中国神经免疫学和神经病学杂志》2002年第4期218-222,共5页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的　报道 6例原发性中枢神经系统淋巴瘤 (PCNSL)患者的临床资料 ,探讨这一少见病的临床特点、诊断及治疗。方法　对 6例 PCNSL患者的临床、影像、病理资料及治疗等进行全面分析。结果　免疫状态改变或病毒感染可能与发病有关。此病男性多见 ,中年为主 ,急性或亚急性起病 ,病程较短 ,进展较快 ,症状、体征多样 ,CT呈等密度或高密度 ,磁共振 (MRI)呈长 T1长 T2 ,周围有水肿 ,有结节状或环状增强 ,组织学符合弥漫型B细胞型非霍奇金淋巴瘤 (NHL) ,对糖皮质激素有一定治疗反应。其中 3例生存期分别已达 9、3 3、3 9个月 ,2例失访 ,1例死亡。结论　结合 PCNSL临床表现、影像及病理学特点可对此病作出诊断 。Objective A series of 6 patients with primary central nervous system lymphoma (PCNSL)was reported, with clinical characteristics , diagnosis and treatment Methods The clinical data including clinical manifestations,radioimages,pathological findings and treatments were thoroughly analyzed. Results The changes of immunological status and virus infection might well be pathogenic to lymphoma production.In our hands,middle aged male preponderance was noted.The disease progressed rapidly with short duration.Sudden or subacute onset was always seen with variable symptom and signs.PCNSL on CT were either isodense or hyperdense with peritumor edema.High T1 and T2 weighted images were seen in MRI.The tumor was enhanced in nodular or ring like fasion. Therapeutic response to corticosteroids was dominant in some NHL cases. Histopathologically NHLs were mainly of diffused, B cell type. 3 cases were alive for 9,33,and 39 months respectively. Conclusions Diagnosis can be made according to clinical manifestation, neuroimage and pathology. Early treatment plays positive role in prognosis.

关 键 词：原发性中枢神经系统淋巴瘤 神经影像 组织病理 PCNSL 临床表现 诊断 治疗 

分 类 号：R739.41[医药卫生—肿瘤]