CD44v6基因表达与胃癌危险因素的关系  

Relationship between CD44v6 expres-sion and risk factors in gastric carci-noma patients.

作　　者：孙喜文[1] 申宝忠[2] 石美森[1] 戴旭东[1] 

机构地区：[1]哈尔滨医科大学肿瘤研究所,黑龙江省哈尔滨市150040 [2]哈尔滨医科大学第三临床医学院,黑龙江省哈尔滨市150040

出　　处：《世界华人消化杂志》2002年第10期1129-1132,共4页World Chinese Journal of Digestology

摘　　要：目的:探索CD44v6拼接变异体(CD44splicevariants,CD44v)的阳性表达与胃癌危险因素的关系.方法:采用病例-病例对照研究方法对胃癌患者进行危险因素暴露调查并采集组织标本,对组织标本经SP免疫组化染色法进行分析.结果:在150例胃癌组织标本中,CD44v表达阳性率为62%.CD44v6阳性表达率的高低与胃癌的浸润深度、TNM分期、淋巴结转移有显著关系(P<0.01).暴露于精神长期处于压抑状态、胃溃疡等因素CD44v6阳性表达率明显高于非暴露者;经常吃大豆及大豆制品(≥3次/wkvs不吃,P<0.001)、经常食用葱蒜类食品CD44v6阳性表达率明显低于不食用者(≥7次/wkvs不吃,P<0.001).在有淋巴结转移的胃癌患者中暴露于三餐不按时、经常吃腌晒盐渍食品(≥7次/wkvs不吃)、慢性萎缩性胃炎和精神长期处于压抑状态等因素CD44v6阳性表达率明显高于非暴露者(P<0.05).结论:CD44v6阳性表达率的高低与胃癌的浸润深度、TNM分期、淋巴结转移有显著关系,与暴露于不良饮食习惯、胃慢性疾病及精神神经因素关系密切,多食用大豆及其制品、经常食用葱蒜类食品具有降低胃癌发病的作用.AIM:To study relationship between expression of CD44v6and some risk factors to which gastric cancer (GC) patientsexposed.METHODS:The case-case control study was conducted toinvestigate the risk factors exposure and the tissue sampleswere collected. The expression of CD44v6 was detected byS-P immunohistochemical technique.RESULTS: The positive rate of CD44v6 was 62% in the 150gastric cancer cases. There were significant associationsbetween expression of CD44v6 and depth of invasion, UICCTNM classification, and lymph node metastasis of gastriccancer (P <0.01). The positive rate was observably higherin the psychic depression for long-term and gastric ulcer expo-sure group than that in the non-exposure group. In patientswith more consumption of beans, shallot and garlic, the ratewas lower than that with lower consumption (P <0.001). Thepositive rate of CD44v6 was higher in exposure to depres-sion model and gastric ulcer than that in control. The lowerpositive rate of CD44v6 was observed in the group of moresoy and soy products consumption(≥ 3 times/wk vs.none, P <0.001) and in the group with frequent shallotand garlic consumption (≥ 7times/wk vs. none, P <0.001). In the lymph node metastasis of gastric cancergroup, the positive rate was higher for exposure fre-quently to salinized food (≥ 7 times/wk vs none), tak-ing meals at irregular times, history of atrophic gastritisand psychic depression (P <0.05). CONCLUSIONS: The expression of CD44v6 is correlated withprogression, metastasis of GC and UICC TNM classification, as well as with some risk factors to which GC patientsexposed.

关 键 词：CD44V6 基因表达 胃癌 危险因素 相关性 

分 类 号：R735.2[医药卫生—肿瘤]