泮托拉唑对消化性溃疡患者胃酸分泌的抑制作用——与奥美拉唑的对照研究  

Intravenous Administration of Pantoprazole Inhibites Gastric Acid Secretion in Peptic Ulcer Patients——Cotrolled Study Versus Omeprazole

作　　者：夏志伟[1] 周丽雅[1] 林三仁[1] 王惠吉[2] 于仲麟[2] 柯美云[3] 刘新光[4] 程留芳[5] 董恩钰[6] 

机构地区：[1]北京大学第三医院消化科,北京100083 [2]北京友谊医院消化科,北京100050 [3]北京协和医院消化科,北京100730 [4]北京大学第一医院消化科,北京100034 [5]解放军总医院消化科,北京100853 [6]中日友好医院消化科,北京100029

出　　处：《中国临床药理学杂志》2002年第5期333-335,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的:观察静脉滴注泮托拉唑对消化性溃疡患者胃酸分泌的影响及其安全性。方法:多中心随机开放对照研究。符合标准的消化性溃疡患者随机分为治疗组（29例）:静脉滴注泮托拉唑40mg;对照组（29例）:静脉滴注奥美拉唑40mg。进行24h胃内pH监测,治疗前后检测血、尿、便常规,肝,肾功能。结果:泮托拉唑治疗组的起效时间（33.5±7.1min）、胃内pH中位数（5.2±2.2）、24h胃内pH≥3（7.9％±7.1％）、≥4（69.1％±5.5％）、≥5（60.5％±6.0％）和≥6（44.6％±6.1％）的时间所占百分比与对照组比较无显著性差异。伴托拉唑治疗组用药后20h内每小时的胃内平均pH均明显高于治疗前。治疗组和对照组均未见明显的药物不良反应发生。结论:静脉滴注泮托拉唑40mg对消化性溃疡患者的胃酸分泌具有较强的抑制作用,且有良好的安全性。OBJECTIVE:To study the inhibitory effect of intravenous administration of pantoprazole on gastric acid secretion in peptic ulcer patients. METHOD: Multicenter , random, open control study design. Peptic ulcer patients met the standards were divided into two groups. Group A(29 case): intravenous pantoprazole 40mg/d, Group B(29 case): intravenous omeprazole 40mg·d-1. All patients received 24hours gastric pH monitoring. RESULT: In group A, after intravenous administration of pantoprazole, the intragastric pH elevated above 4 in 33.5 ±7.1 minutes, which had no significant difference with that in group B. The percent age of intragastric pH ≥ 3,3≥4,≥ 5 and ≥ 6 in 24 hours in group A was 74.9% ± 7.1%, 69.1% ± 5.5%, 60.5% ± 6.0% and 44.6% ± 6.1%, respectively, no difference with those items in group B. There was no obvious side effect in both groups. After the intravenous administration of pantoprazole, the intragastric pH kept significantly higher than pre-treament in 20 hours. Conclusion: Pantoprazole for intravenous administration is a effective and safe agent.

关 键 词：泮托拉唑 消化性溃疡 胃酸分泌 抑制作用 奥美拉唑 对照研究 

分 类 号：R573.1[医药卫生—消化系统] R975.6[医药卫生—内科学]