层粘连蛋白及其受体在人正常绒毛、葡萄胎组织中的表达及意义  

The expression of laminin and laminin receptor in human villi and hydatidifore mole

作　　者：安瑞芳[1] 刘惠喜[1] 张晨[1] 李芬[1] 

机构地区：[1]西安交通大学第一医院妇产科,西安710061

出　　处：《西安交通大学学报（医学版）》2002年第5期458-460,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的　探讨层粘连蛋白 (LN) ,层粘连蛋白受体 (LN R)与葡萄胎发生的关系。方法　采用免疫组织化学方法 ,观察正常人胚胎早期绒毛、葡萄胎组织中LN、LN R的表达情况。结果　LN在正常绒毛组织、葡萄胎组织基底膜着色呈连续线状 ,其表达与妊娠周数有关 ,随着妊娠周数的增加LN的表达呈下降趋势。正常绒毛组织、葡萄胎组织中LN R的表达位于上皮组织细胞膜上 ,呈阳性包绕状 ,且在偏离基底膜细胞表面着色较深。结论　推测LN R在细胞膜表面的分布可反映细胞的生长、浸润的方向 ,葡萄胎组织中LN、LN R的表达在研究葡萄胎发病机制上有一定的参考价值。Objective To investigate the relationship between laminin (LN), laminin receptor (LN-R) and the onset mechanism of hydatidiform mole. Methods Immunohistochemical method was used to detect the expression of LN, LN-R in human villi and hydatidiform mole. Results LN was stained in continued-lining shape both at the site of basal membrane cellular membrane and surrounded by positive staining which was thicker on the side of normal villi and hydatidiform mole. The staining corresponded negatively to gestational weeks. The expression of LN-R in both basal membrane of normal villi and hydatidiform mole was sited on the surface epithelial membrane. Conclusion Lamine and its receptor might play an important role in the occurrence of hydatidiform mole.

关 键 词：层粘连蛋白 绒毛 葡萄胎 层粘连蛋白受体 免疫组织化学 临床意义 

分 类 号：R737.33[医药卫生—肿瘤]