癫痫发作前后即刻血浆NO、ET_1浓度的研究  

Stutly on the Concentrations of NO and ET, in Plasma around Epileptic Attack

作　　者：黄怀宇[1] 黄志东[1] 顾承志[1] 沈均[2] 王增辉[2] 史春兰 马鹏林 

机构地区：[1]江苏省南通市第一人民医院,226001 [2]南通市通济医院

出　　处：《神经疾病与精神卫生》2002年第5期263-264,共2页Journal of Neuroscience and Mental Health

基　　金：南通市社会发展科技计划项目资助(S9808)

摘　　要：目的 观察NO、ET_1在癫痫发作的即时血浆浓度的变化。方法 对精神疾病符合电休克(ECT)治疗标准患者,ECT诱发癫痫发作进行治疗,在治疗前后5分钟测定患者血浆NO、ET_1。结果癫痫发作后NO、ET_1均有明显升高(P<0.05)。结论 NO可能参与了癫痫的发生、扩散,ET_1在缺氧状态下体内会加速释放,更加剧了组织缺氧。To probe the concentrations changing of NO and ET1 in plasma around epileplic attack. Methods In patients according with electro- shock treatment ( ECT) standar, with ECT inducing episptic attack,then treating. The concentrations of NO and ET1 were detected during 5 minutes before and after treatment. Results The concentrations of NO and ET1 increased obviously after epileplic attack.Conclu-sio NO is the main factor which causing epilepsy attack a A proliferation. ET1 increases in hypoxia state and aggravates tissue anoxia.

关 键 词：癫痫发作 癫痫 电休克 一氧化氮 内皮素 即时血浆浓度 

分 类 号：R742.1[医药卫生—神经病学与精神病学]