肿瘤细胞增生活性与膀胱移行细胞癌生物学行为关系的研究  

THE RELATIVITY OF TUMOR PROLIFERATIVE ACTIVITY AND BIOLOGICAL BEHAVIOUR OF TRANSITIONAL CELL CARCINOMA OF BLADDER

作　　者：宋旭[1] 汤鹏[1] 漆贯华[1] 李业宽[1] 

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223300

出　　处：《肿瘤研究与临床》2002年第5期316-318,共3页Cancer Research and Clinic

摘　　要：目的 :检测 Ki- 6 7抗原在膀胱移行细胞癌 (TCC)中的表达 ,研究肿瘤增生活性与肿瘤生物学行为的关系。方法 :应用免疫组化 SP法检测 45例膀胱 TCC和 12例正常膀胱组织 Ki- 6 7抗原的表达。Ki- 6 7标记指数 (Ki- 6 7L I)指染色阳性细胞占全部细胞的百分数。其分级标准为 :无阳性细胞为— ,阳性细胞 <2 5 %为 +,≥ 2 5 %、<5 0 %为 ++,≥ 5 0 %、<75 %为 +++,≥ 75 %为 ++++。结果 :Ki- 6 7抗原阳性表达率膀胱 TCC组为 48.47% ,对照组为 8.33% (P=0 .0 11) ;临床分期 Ta～ T1 为 35 .71% ,T2 ～ T4为 76 .47% ,病理分级 G1 为 2 5 % ,G2 为 5 3.33% ,G3 为 90 %。随着肿瘤分期分级升高 ,Ki- 6 7L I逐渐上升 (P=0 .0 0 4,P=0 .0 0 1)。Ki- 6 7L I肿瘤复发、多发者明显高于初发、单发者 (P=0 .0 14,P=0 .0 34 )。结论 :细胞无限增生是肿瘤形成的重要原因 ,Ki- 6 7L I能准确地评估膀胱 TCC的生物学行为 ,可作为膀胱Objective:To study the expression of Ki-67 in transitional cell carcinoma of bladder and evaluate the relativity of tumor proliferative activity and biological behaviour of transitional cell carcinoma of bladder.Methods:The expression of Ki-67 were detected by immunohistochmistry (SP).The Ki-67 Labeling Index (Ki-67LI,the number of Ki-67 positive tumor cells divided by the total number of tumor cells expressed in percent) was assigned a value of -,1+,2+,3+ and 4+ according to its position in the bands (0,<25 %,≥25 % and <50 %,≥50 % and <75 %,≥75 %).Results:Expression of Ki-67 was observed in 48.87 % of TCCs and 8.33 % of controls (P=0.011). It was also found in 35.71 % of T a～T 1 and 76.47 % of T 2～T 4, and 25 % of G 1, 53.53 % of G 2 and 90 % of G 3.With the progress of clinical stage and grade,the positive rate of Ki-67 expression increased (P=0.004,P=0.001).Furthermore,the Ki-67LI of recurrent and multiple lesions were greater than that of primary and single lesions (P=0.014,P=0.034).Conclusion:The deragulative proliferation is an important cause of neoplastic tumor formation.Ki-67LI can accurately evaluate the biological behaviour of bladder TCCs,and might act as an useful tumor markers.

关 键 词：肿瘤细胞增生活性 膀胱移行细胞癌 生物学行为 研究 膀胱肿瘤 KI-67 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]