CD44v6表达与胃癌临床病理因素及预后的关系  

Expression and prognostic significance of CD44v6 in primary gastric carcinoma

作　　者：周烨[1] 朱慰祺[1] 师英强[1] 施达仁[2] 陆洪芬[2] 

机构地区：[1]复旦大学附属肿瘤医院腹部外科,上海200032 [2]复旦大学附属肿瘤医院病理科,上海200032

出　　处：《中国癌症杂志》2002年第5期391-394,共4页China Oncology

摘　　要：目的:研究CD44v6在胃癌组织中的表达,评估其在胃癌预后中的地位。方法:采用免疫组织化学EnVision^(TM)法,检测42例远隔癌灶部位"正常"胃粘膜和188例手术切除的胃癌组织中CD44v6的表达,并分析其与临床、病理特征的关系及对预后的影响。结果:CD44v6在胃癌组织中的阳性率为67.6%,明显高于远隔癌灶部位"正常"胃粘膜的表达(9.5%)(P<0.01),并与淋巴结转移有关(P<0.05)。Kaplan-Meier生存分析结果表明CD44v6表达与总生存率和无瘤生存率均显著相关(p<0.01),多因素分析结果表明脉管侵犯、TNM分期和CD44v6表达是影响胃癌患者生存率的独立预后因素(P<0.05)。结论:CD44v6在胃癌组织中具有较高的表达,有可能成为判断胃癌预后的有用指标。Purpose:To study the relationship between the expression of CD44v6 with the clinicopathological charac- teristics and the prognosis in primary gastric carcinoma patients.Methods:A total of 188 paraffin-embedded gastric carcino- mas and 42 non-carcinomatous gastric mucosae was stained with the monoclonal antibodies CD44v6 using the EnVision^(TM) method.Results:The expression level of CD44v6 were significantly higher in the tumors (67.6%) than in the non-carcino- matous gastric mucosae (9.5%) (P<0.01).The expression level of CD44v6 protein was related to lymph node metastasis (P<0.05).Kaplan-Meier analysis revealed that patients with CD44v6-negative cancers had prolongation of overall survival (OS) and disease-free survival (DFS) (P<0.01).By multivariate analysis,it demonstrated that vessel invasion,TNM stage and CD44v6 expression played important roles in OS or DFS (P<0.05).Conclusions:The results suggest that CD44v6 is frequently expressed in primary gastric carcinoma,and CD44v6 might be used as one of the markers of poor prognosis in patients with gastric carcinoma.

关 键 词：表达 CD44V6 胃癌 临床病理指标 预后 相关性 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]