具有微灶钙化、临床未能触及肿块的乳腺癌的早期诊断  

Early detection of breast cancer with microcalcification but without palpable mass

作　　者：张廷璆[1] 柳光宇[2] 顾雅佳[3] 刘权[3] 

机构地区：[1]复旦大学附属肿瘤医院病理科,上海200032 [2]复旦大学附属肿瘤医院外科,上海200032 [3]复旦大学附属肿瘤医院放射科,上海200032

出　　处：《中国癌症杂志》2002年第5期444-446,共3页China Oncology

摘　　要：目的:探讨乳腺X线摄片显示微灶钙化但临床未触及肿块患者的早期诊断方法。方法:乳腺X线片内显示微灶钙化的57例,有35例进行了乳腺X线立体定位空心针活检,23例进行了乳腺X线立体定位手术活检。穿刺活检或手术切除标本经常规制片,光镜下对钙化灶进行定位,半定量及钙化灶形态的观察、分析。并进行组织学的诊断。结果:经乳腺X线立体定位空心针活检的35例中,24例镜下见钙化灶,诊断导管内癌8例,浸润性导管癌4例。经X线立体定位手术活检的23例中,20例见钙化灶,诊断导管内癌5例,浸润性导管癌3例,浸润性小叶癌1例。结论:通过病理科、外科、放射科医师的密切合作,应用乳腺X线立体定位空心针活检及手术活检方法,对临床未触及肿块,乳腺X线摄片显示微灶钙化的患者,可以早期发现乳腺癌,最终以提高乳腺癌患者的生存期。Purpose:To investigate method of early detection of breast cancer with microcalcification observed by mammograph but without palpable mass clinlcally.Methods:Stereotatic core needle biopsy (SCNB) were performed in 35 patients with calcification observed by mammography,and 29 people received stereotatic needle localized breast biopsies (NLBB).All tissues were routinely processed.Microscopic analysis of calcification and morphologic analysis of calcifica- tion were done,as well as histologic diagnosis.Results:Among the 35 specimens of SCNB,microscopic calcification,in- traductal carcinoma and invasive ductal carcinoma were detected in 24,8,and 4 respectively.Calcification was identified in 25 of the 29 cases of NLBB.Five cases of intraductal carcinoma,six cases of invasive ductal carcinoma as well as one case of invasive lobular carcinoma were diagnosed in these 29 patients.Conclusions:With close cooperation among pathol- ogists,surgeons and radiologists,the application of SCNB and NLBB may benefit the early detection of breast cancer with microcalcification observed by mammograph but without mass being palpable clinically and finaly improve the survival of breast cancer patients.

关 键 词：早期诊断 乳腺癌 X线立体定位 空心针活检 手术活检 

分 类 号：R737.9[医药卫生—肿瘤] R730.4[医药卫生—临床医学]