思美泰治疗妊娠肝内胆汁淤积症的临床观察  

A Clinical Observation of S-adenosylmethionine on Treating the Intrahepatic Cholestasis during Pregnancy

作　　者：赵小环[1] 姚琦玮[1] 王正平[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《浙江预防医学》2002年第12期9-10,共2页Zhejiang Journal of Preventive Medicine

摘　　要：目的　探讨思美泰治疗妊娠肝内胆汁淤积症 (ICP)的临床效果。方法　采用思美泰治疗 60例ICP患者 ,治疗前后测定血清甘胆酸 (CG)和肝功能。治疗组妊娠结局与同期未经治疗的 12 0例ICP患者作对照。结果　治疗前后比较 ,血清CG、ALT、AST有显著性下降 (P <0 0 1) ,瘙痒症状减轻 ,黄疸消退。治疗组羊水污染发生率、胎儿窘迫发生率均明显低于对照组 (P <0 0 5 )。未发现药物对母儿的不良反应。结论　思美泰治疗ICP安全有效 ,值得临床推广。ObjectiveTo study the effect of S-adenosylmethionine (SAMe) on the treatment of Intrahepatic Cholestasis during pregnancy (ICP).MethodsThe serum cholyglycine (CG), aminotransferases (ALT, AST) and bilirubin of 60 ICP patients treated with SAMe were measured at pretreatment and post-treatment respectively, which was compared to 120 ICP patients without the treatment during the same period.ResultsLevels of CG, ALT and AST decreased significantly after treatment (p<0.01). The symptom of prurituds was relieved, and jaundice was disappeared. The incidence rate of either meconium staining in amniotic fluid or fetal distress in the treatment group was significantly lower than that in the group without treatment (p<0.05). No adverse effect was found in both of mother and baby. ConclusionsSAMe is safe and effective in the treatment of ICP and it is worth widely using in clinic.

关 键 词：治疗 思美泰 妊娠 胆汁淤积症 ICP 

分 类 号：R714.255[医药卫生—妇产科学] R969.4[医药卫生—临床医学]