洛阳市肝癌危险因素的病例对照研究  

THE CASE-CONTROL STUDY FOR THE RISK FACTORS OF HCC IN LUOYANG

作　　者：汤伯明 边建超[2] 王其军 王刚[2] 王启敏 黄传继[3] 朱鑫 樊巍巍 张竹梅[2] 黎江[2] 

机构地区：[1]河南省洛阳市卫生防疫站流行病防治所,471000 [2]复旦大学公共卫生学院流行病学教研室,200032 [3]解放军第150中心医院肿瘤科,471031

出　　处：《现代预防医学》2002年第5期723-725,共3页Modern Preventive Medicine

基　　金：国家自然科学基金 (3 9870 65 4)

摘　　要：目的 :探讨中国肝癌低发区肝癌的危险因素 ,为肝癌的预防提供科学依据。方法 :采用病例对照研究设计 ,以5 0例肝癌患者和 73例健康对照作为研究对象 ,询问其暴露史 ,然后应用 SAS软件进行单因素和多因素非条件 logistic回归分析。结果 :单因素非条件 logistic回归分析表明 ,乙肝病史、亲属肿瘤史、疟疾、水果、吸烟是肝癌的危险因素 ,其比值比分别为 99.4 3、 7.4 6、 3.80、 2 .90和 2 .35 ;月经异常是女性肝癌的危险因素 ,其比值比为 4 .2 5 ;蔬菜和自来水是肝癌的保护因素 ,其比值比分别为 0 .4 2和 0 .14。多因素非条件 logistic回归分析表明 ,乙肝病史、亲属肿瘤史、疟疾、精神创伤、吸烟和油炸食品是肝癌的危险因素 ,其比值比分别为 89.2 3、 35 .5 2、 17.19、 3.88、 4 .39和 4 .2 7;2 0年前生活水平是肝癌的保护因素 ,其比值比为 0 .2 3。讨论内容 :肝癌是多因素所致的恶性肿瘤 ;水果成为肝癌的危险因素 ,可能是患乙肝后所致的偏倚 ;Objective:To explore the risk factors of HCC in the areas of low incidence for HCC in China and provide proofs for control of HCC.Methods:Using the design of case control study, 50 patients with HCC and 73 healthy controls were selected as the subjects, whose exposure histories were inquired. Monofactorial and multifactorial non conditioning logistic regressive analyses were carried out.Results:The results of monofactorial non conditioning logistic regressive analysis showed that history of hepatitis B, history of cancers in the relatives, history of malaria, eating fruits habitually and smoking were the risk factors for HCC, and their odds ratios were 99 43, 7 46, 3 80, 2 90 and 2 35,respectively, that abnormal menstruation was the risk factor for HCC in women, and its odds ratio was 4 25, that eating vegetables habitually and drinking tap water were the protective factors for HCC, and their odds ratios were 0 42 and 0 14,respectively. The results of multifactorial non conditioning logistic regressive analysis showed that history of hepatitis B, history of cancers in the relatives, history of malaria, history of psychic trauma, smoking and eating fried foods habitually were the risk factors for HCC, and their odds ratios were 89 23,35 52, 17 19, 3 88, 4 39 and 4 27,respectively, and that higher living status 20 years before was the protective factor for HCC, and its odds ratio was 0 23. Conclusions:HCC is a kind of malignancy resulted from the multifactors.Fruits was the risk factor and may be the bias resulted into hepatitis B. It is first reported that eating fried foods habitually and abnormal menstruation are associated with HCC.

关 键 词：洛阳市 肝癌 危险因素 病例对照研究 

分 类 号：R735.7[医药卫生—肿瘤]