感染性脑水肿发生的机理研究  

Pathogenic Mechanism of Infective Brain Edema

作　　者：张国元[1] 黄榕[1] 杨于嘉[1] 徐正谷[1] 

机构地区：[1]中南大学湘雅医院儿科,湖南长沙410008

出　　处：《中国医师杂志》2002年第10期1059-1060,共2页Journal of Chinese Physician

摘　　要：目的　观察实验性感染性脑水肿时β -内啡肽 (β -EP)的变化以探讨感染性脑水肿的发病机理。方法　采用兔百日咳菌液感染性脑水肿模型 ,观察生理盐水组 (NS ,n =7)、百日咳菌液组 (PB ,n =7)两组兔脑组织含水量、大脑皮层、海马、血浆及脑脊液中 β -EP含量变化。 结果　PB组脑组织含水量显著高于NS组 (P<0 0 1) ,大脑皮层、海马、血浆及脑脊液中 β -EP含量分别为 (5 6 2 8± 11 6 6 )pg/mg ,(85 97± 33 76 )pg/mg ,(10 6 33± 2 4 96 )ng/ml,(2 4 9± 0 6 6 )ng/ml,均显著高于NS组 (18 5 0± 2 0 1)pg/mg ,(2 2 5 2± 6 0 7)pg/mg ,(43 80± 19 6 3)ng/ml,(1 14± 0 39)ng/ml,P均小于 0 0 1)。结论　感染性脑水肿时 ,大脑皮层、海马、血浆及脑脊液中β -EP含量明显增加 ,引起脑水肿的发生和发展。Objective To understand the pathogenic mechanism of β-endorphin(β-EP) on infective brain edema(IBE).Methods Experimental IBE was induced by pertussis bacilli in rabbits.Forteen rabbits were divided randomly into two groups:Normal saline group(NS,n=7),pertussis bacilli group(PB,n=7).Water content(WC) in brain tissue and β-EP were measured in plasma,cerebrospinal fluid(CSF),cortex and hippocampus in two groups respectively.Results WC was singnificantly higher in the PB group than those in the NS groups(P<0.01). β-EP of the cortex,hippocampus, plasma,and CSF were singnificantly higher in the PB group than those of NS group;(56.28±11.66) pg/mg vs (18.50±2.01)pg/mg,(85.97±33.76)pg/mg vs(22.52±6.07)pg/mg,(106.33±24.96)ng/ml vs (43.80±19.63)ng/ml,(2.49±0.66)ng/ml vs (1.14±0.39)ng/ml,(P<0.01),respectively.Conclusions β-EP of the cortex,hippocampus,plasma and CSF are significantly increased in the infective brain edema,it leads to the occurrence and developing of brain edema.

关 键 词：感染性脑水肿 百日咳菌液 Β-内啡肽 发病机理 动物实验 

分 类 号：R748[医药卫生—神经病学与精神病学]