左旋多巴促进兔下颌骨缺损愈合的实验研究  

Experimental Study on Healing of the Mandibular Defect of Rabbit By L-Dopa

作　　者：喻建军[1] 沈子华[2] 刘蜀凡[2] 李海平[2] 

机构地区：[1]湖南省肿瘤医院,湖南长沙410006 [2]中南大学湘雅医院

出　　处：《中国医师杂志》2002年第10期1063-1065,共3页Journal of Chinese Physician

摘　　要：目的　研究口服国产左旋多巴对兔下颌骨人工缺损愈合过程的影响。方法　 5 2只家兔随机分为实验组和对照组 ,于下颌骨形成人工缺损后 ,实验组给左旋多巴口服 ,于术后 14、2 1、30、4 2、4 9d ,分别取局部缺损骨愈合标本 ,观察其X片 ,组织学变化 ,计算骨形态计量学参数。结果　X线片显示实验组缺损从 30d起 ,均显示出满意的骨性连结影像 ,对照组均有数例骨缺损没有出现X线片上的良好连接 ,组织学检查也得出相同的结论 ,骨组织计量学测量显示 ,在 30d时 ,实验组TBV值与对照组之间差异有显著性 (P <0 0 1) ,表示成骨细胞活性的SV -OSB值 ,表示类骨的OS - 1%值 ,及表示类骨矿化速率的AR/D值在两组间差异有显著性 (P <0 0 5 )。结论　左旋多巴对兔颌骨骨愈合有一定的促进作用。Objective The effect of oral L-Dopa on healing of the experimental mandibular defect of rabbits was studied.Method 52 rabbits were assigned randomly to experimental group and control group.After bone defect being made on mandible,rabbits had been given with L-Dopa in experimental group.Healing bone samples were adopted at 14,21,30,42,49 days after operation,observed x-ray and histological changes and calculated out the bone histomorphometric parameters.Results X-ray inspection indicated that bone defect of the experimental group had completed callus union from 30th day.But,a part of the defect of control group did not appear callus union radiologically.Histological examination had the same result.Bone histormorphometry examination exhibited that there was a significant difference between TBV of the experimental and the control group(P<0.01).SV-OSB value representing the osteoblast activity,OS-1% value represented the osteoid amount and AR/D value demonstrated mineralization velocity of the osteoid showed signhificant difference between the two groups(P<0.05).Conclusion L-Dopa have definite positive effect in some extent on the healing of the mandible of rabbit.

关 键 词：下颌骨骨缺损 左旋多巴 骨形态学 动物模型 

分 类 号：R782.4[医药卫生—口腔医学]