慢性便秘胃肠激素的变化  

The Changes of Gastrointestinal Hormones in Chronic Constipation

作　　者：尤汉宁[1] 许幼如[1] 王彝康[1] 孙依萍[1] 李定国[1] 

机构地区：[1]上海第二医科大学附属新华医院消化科,上海200092

出　　处：《中国医师杂志》2002年第10期1081-1081,1083,共2页Journal of Chinese Physician

摘　　要：目的　研究慢性便秘胃肠激素的变化。方法　门诊慢性便秘患者 17例 ,正常对照 10例 ,空腹采血 ,采用RIA法检测生长抑素 (SS)和P物质 (SP)的水平。结果　慢性便秘患者SS和SP的水平分别为 (12 0 5 7±2 7 84 )pg/ml及 (7 6 8± 2 5 )pg/ml。与对照组比较 ,差异有显著性 (P <0 0 1)。结论　胃肠激素的变化在慢性便秘的发病中起着一定的作用。Objectives To study the changes of gastrointestinal hormones in chronic constipation. Methods 17 outpatient chronic constipation patients, and 10 normal persons were respectively chosen as observation group and control group. Fasting blood samples were taken in all patients. The serum levels of somatostatin (SS) and substance P (SP) were tested using RIA method.Results The serum level of SS and SP in observation group were (120.57±27.84)pg/ml and (7.68±2.5)pg/ml respectively, significantly higher than that in control group (P<0.01).Conclusions The changes of gastrointestinal hormones might play some roles in the pathogenesis of chronic constipation.

关 键 词：RIA法 胃肠激素 慢性便秘 生长抑素 P物质 发病机制 

分 类 号：R574[医药卫生—消化系统]