光致反应合成萘普生  

SYNTHESIS OF NAPROXEN BY PHOTO REACTION

作　　者：杜汝励[1] 黄文伟[1] 

机构地区：[1]暨南大学化学系

出　　处：《暨南大学学报（自然科学与医学版）》1991年第3期46-49,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：省自然科学基金

摘　　要：萘普生(Naproxen简称NPX)是一种高效非甾体抗炎解热镇痛新药。采用光致S_(RNI)反应,由β—萘酚为起始原料,经3步合成dl-NPX。第2步光致反应中,选择了最佳条件:反应物(?)CN:K:BMN(mol)=1.13:1:0.1。以乙二胺为溶剂,在N_2保护下,室温搅拌,光照2小时,得腈(Ⅱ),产率为90.6％～93.8％。d—2—(6—methoxy—2—naphthyl) propionic acid (naproxen) is a novel antipyretic analgesics. It was synthesised from 2-methoxyl naphthalene byphoto reaction through three steps. The optimum conditions are CH_3H_2 CN: K: BMN=1.13:1:0.1 by mol, in solvent H_2NCH_2CH_2NH_2. at room temperature exposed to light for 2h. The nitrile(Ⅱ) yield ranges from 90.6% to 93.8%. The method is simple for its easy operation, short reaction time and high yield, as compared to those in previous reports.

关 键 词：萘普生 合成 光致反应 解热镇痛药 

分 类 号：TQ463.4[化学工程—制药化工]