动脉栓塞治疗子宫肌瘤三种栓塞剂动物实验比较研究  

Uterine Arterial Embolization Therapy for Leiomyoma-A Comparative Study of Three

作　　者：梁善言[1] 张强[1] 王树厚[1] 王浩洲[1] 吴越[1] 吴红军[1] 栾贻涛[1] 张文斌[1] 

机构地区：[1]解放军第88医院介入治疗中心,山东泰安271000

出　　处：《实用放射学杂志》2002年第10期833-835,共3页Journal of Practical Radiology

摘　　要：目的　通过比较聚乙烯醇 (PVA)微粒 ,平阳霉素碘油乳剂和无水酒精三种子宫肌瘤动脉介入治疗栓塞剂治疗结果 ,为介入栓塞剂临床应用的选择提供实验基础。方法　对 3 6只成年狗的子宫分别应用聚乙烯醇 (PVA)微粒 ,平阳霉素碘油乳剂和无水酒精三种栓塞剂 ,进行双侧子宫动脉栓塞 ,观察子宫病理变化和萎缩的情况。结果　栓塞术后 7、14、2 8d ,发现无水酒精组子宫发生了坏死穿孔 ,PVA和平阳霉素碘油乳剂组子宫缩小 7.3 %～ 2 8.2 % ,无严重并发症发生。结论　PVA和平阳霉素碘油乳剂是一种良好的子宫动脉栓塞剂 ,无水酒精应慎用。Objective To assess the curative effects,side effects and complications of arterial embolization for the treatment of uterine leiomyomas.Methods Adult female dogs were used in this study.Each time point each group 4 animals.Thirty six dogs were randomly divided into three groups:PVA group(n=12),PYM group(n=12) and Ethanol group(n=12).Bilateral uterine arterial embolization was performed in 36 dogs with there agents.After operation light microscope was used to examine uterine pathology,the size of uterine was observed during follow-up checkups.Results After operation 7,14,28 days.The uterine size was decreased by 7.3%～28.2% in PVA and PYM groups.No serious complications occurred.Most uteri of ethanol group developed necrosis and perforation.Conclusion PVA and PYM are effective therapy agents for patients with uterine leiomyomas.The application of ethanol for uterine arterial embolization should be prudently.

关 键 词：动脉栓塞 治疗 子宫肌瘤 动物实验 聚乙烯醇 平阳霉素碘油乳剂 无水酒精 

分 类 号：R737.33[医药卫生—肿瘤] R730.55[医药卫生—临床医学]