不同MR扫描序列在SPIO增强大鼠肝癌模型的对比研究  

The comparison of different MR sequences in rat HCC model after superparamagnetic iron oxide enhancement

作　　者：刘岘[1] 许乙凯[1] 黄其鎏[1] 

机构地区：[1]第一军医大学附属南方医院影像中心,广州510515

出　　处：《放射学实践》2002年第5期425-427,共3页Radiologic Practice

摘　　要：目的 :比较多种扫描序列超顺磁氧化铁 (SPIO)增强扫描对显示大鼠肝癌病灶的能力 ,找出最佳扫描方案。方法 :制作二乙基亚硝胺诱发的大鼠肝癌模型 ,在注射SPIO对比剂增强前后 ,分别行MR扫描 ,扫描序列包括SET1WI、TSET2 WI、SE双回波的T2 WI +PDWI、GRET1WI、T2 WI ,分析增强前后大鼠肝癌病灶的强化特征 ,并进行病理学检查对照分析。结果 :注射SPIO对比剂后 ,所有扫描序列均显示肝脏的信号强度较增强前有不同程度的下降 ,肝癌病灶CNR均分别高于平扫。增强后GRET2 WI中病灶的CNR明显高于其它序列 ,但增强后TSET2 WI和常规SET2 WI在显示病变的SNR、CNR方面没有显著性差异。结论 :SPIO增强后检测肝癌病灶的各种序列中 ,以GRET2 WI最为敏感 ,其次是双回波的T2 WI +PDWI序列。Objective:To evaluate the different MR sequences in visualization of hepatocellular carcinoma (HCC) rat model after administration of superparamagnetic iron oxide(SPIO),and to seek the optimal scanning parameter.Methods:Experimental model of hepatocellular carcinoma was induced in 20 rats by feeding DEA.MR imaging was performed before and after SPIO injection using SE T 1W,TSE T 2W,T 2W+PDW of SE dual echo,GRE T 1W and T 2 *W sequences.Their characteristics of MR enhancement were evaluated by calculating SNR and CNR of tumors and correlated to the pathological findings.Results:After SPIO enhancement, signal intensity of liver decreased in varying degree in all sequences;the contrast to noise ratio of HCC was greater than that before enhancement in all sequences;and the CNR in GRE T 2 *WI was significantly greater than that in the other sequences,but there was no difference between Turbo SE and conventional SE sequence in the CNR and SNR.Conclusion:With SPIO enhancement,GRE T 2 *W and T 2W+PDW of SE dual echo sequences are the most sensitive sequences.

关 键 词：SPIO 肝癌 磁共振成像 动物模型 

分 类 号：R735.7[医药卫生—肿瘤] R730.49[医药卫生—临床医学]