羟乙基淀粉200注射液治疗小血管病变导致的后循环缺血性眩晕的疗效观察  

Hydroxyethyl starch injection treatment of 200 small vascular lesions caused by clinical observation of posterior circulation ischemic vertigo

作　　者：张振芳[1] 司秋霞[1] 王雯[1] 赵娜[1] 黄静[1] 

机构地区：[1]沧州市中西医结合医院,河北沧州061001

出　　处：《中医临床研究》2016年第12期42-45,共4页Clinical Journal Of Chinese Medicine

基　　金：沧州市科技支撑计划(编号:141302020)

摘　　要：目的:观察羟乙基淀粉200注射液治疗小血管病变导致的后循环缺血性眩晕(Posterior Circulation Ischemic Vertigo,PCIV)的临床疗效。方法:选取2014年1月—2014年12月在我院脑病科住院的90例经头MRI、MRA、DWI确诊的后循环缺血性眩晕患者,随机分为羟乙基淀粉治疗组45例和对照组45例,观察治疗前及治疗后7 d、(14±2)d,眩晕评估评分量表(Dizziness Assessment Rating Scale,DARS)评分、眩晕障碍调查表(Dizziness Handicap Inventory,DHI)评分及经颅多普勒超声(transcranial Doppler sonography,TCD)、脑干听觉诱发电位(Brainstem Auditory Evoked Potential,BAEP)的变化。结果:羟乙基淀粉扩容治疗组较对照组,能明显改善眩晕患者的临床症状,两组患者DARS评分和DHI评分,两组均呈下降趋势,组间差异明显(P<0.01);两组患者TCD的变化结果,治疗前扩容治疗组异常率为82.2%(37/45),对照组治疗前异常率为86.7%(39/45),治疗后扩容治疗组异常率为15.7%(7/45),对照组异常率为37.8%(17/45);两组均呈下降趋势,但扩容治疗组下降更明显,组间差异具有统计学意义;BAEP的变化,治疗前扩容治疗组异常率为77.78%(35/45),对照组治疗前异常率为71.1%(24/45),治疗后扩容治疗组异常率为17.8%(8/45),对照组异常率为42.2%(19/45);两组异常率均呈有所下降,组间差异具有统计学意义。结论:羟乙基淀粉200/0.5注射液能够快速、有效地改善小血管病变导致的后循环缺血的症状。Objective: To observe the clinical efficacy of hydroxyethyl starch injection in the treatment of 200 small vascular lesionscaused by posterior circulation ischemic vertigo (posterior circulation ischemic vertigo, PCIV). Methods: 90 cases diagnosed with posteriorcirculation ischemic vertigo in our hospital between January 2014 to December 2014 in encephalopathy department after the head MRI,MRA, DWI were randomly divided into treatment group and control group, 45 cases each group. Hydroxyethyl starch were observed 7days before and after treatment, and vertigo Assessment Rating Scale (Dizziness Assessment Rating Scale, DARS) score, vertigo disorderquestionnaire (Dizziness Handicap Inventory, DHI) score and transcranial Doppler sonography (TCD) and Brainstem auditory evokedpotential (BAEP) changes were observed after (14±2) days of treatment . Results: Hydroxyethyl starch expansion in Treatment group cansignificantly improve the clinical symptoms in patients with vertigo than those in the control group. DARS rating and DHI scores in bothgroups declined and the differences between the groups were significant (P<0.01). TCD changes were observed in both groups aftertreatment, abnormal rate before treatment were 82.2% (37/45) and 86.7% (39/45), respectively, in treatment group and control group, andthe values after treatment were 15.7% (7/45) and 37.8% (17/45); Decline was observed in both groups, but the decline in the treatmentgroup were more obvious, and the difference between group was statistically significant. Abnormal BAEP changes were observed in bothgroups, before the treatment abnormal rate were 77.8% (35/45) and 71.1% (24/45), respectively, in the treatment group and control group,and the values after treatment were 17.8% (8/45) and 42.2% (19/45); Abnormal rate were decreased in both groups, and there wassignificant difference between the groups. Conclusion: hydroxyethyl starch injection can quickly and efficiently improve the 200/0.5 small vascular lesions caused by posterior circulation ischemia symptoms.

关 键 词：羟乙基淀粉200 注射液 小血管病变 扩容治疗 后循环缺血性眩晕 

分 类 号：R741[医药卫生—神经病学与精神病学]