基于复杂网络的《伤寒论》六经病证用药规律研究  

Study on Medication Principles of Six Channel Syndrome of Treatise on Cold Damage Disorders Based on Complex Network

作　　者：李瀛[1] 隋毅[2] LI Ying;SUI Yi(Medical College, Shandong University, Jinan 250012, China;College of Computer Science Technology, Qingdao University, Qingdao 266071, China)

机构地区：[1]山东大学医学院,山东济南250012 [2]青岛大学计算机科学技术学院,山东青岛266071

出　　处：《中国中医药信息杂志》2016年第8期37-41,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金重大研究计划(91130035);山东省自然科学基金重点项目(ZR2012FZ003)

摘　　要：目的建立《伤寒论》六经病证药物子网,基于药物子网的拓扑性质分析,揭示《伤寒论》六经病证用药规律。方法将《伤寒论》方剂按照六经辨证进行分类,采用复杂网络理论将药物抽象为节点,分别建立太阳、阳明、少阳、太阴、少阴、厥阴六经病证药物子网,分析各药物子网的节点度、网络连通性拓扑性质。结果治疗太阳病、太阴病的主要药物为桂枝、芍药、大枣、生姜、甘草;治疗阳明病的主要药物为大黄、人参、杏仁;治疗厥阴病的主要药物为干姜、当归、细辛;治疗少阴病的主要药物为附子、茯苓;治疗少阳病仅小柴胡汤数据。任意两经子网间公共节点计算显示,治疗太阳、阳明、厥阴、少阴病的方剂具有较多相同药物,太阴与少阳病证药物子网数据较少,且多为其他经子网方剂添加少量新药物而组成。结论《伤寒论》六经病证的用药规律存在差异,对研究《伤寒论》辨证论治机制具有一定意义。Objective To establish six channel herbal networks for Treatise on Cold Damage Disorders based onanalysis of topological properties of medicinal subnets; To reveal the medication principles of six channel syndromein Treatise on Cold Damage Disorders. Methods Prescriptions in Treatise on Cold Damage Disorders werecategorized according to six-channel syndrome differentiation. Complex network theory was used to abstractmedicine as nodes, and medicinal subnets for six channel syndrome of Taiyang, Yangming, Shaoyang, Taiyin,Shaoyin, Jueyin were established respectively. Node degrees and network connectivity of topological property foreach medicinal subnet were analyzed. Results The main herbal medicines for Taiyang and Taiyin diseases wereCinnamomi Ramulus, Chinese herbaceous peony, Jujubae Fructus, Zingiberis Rhizoma Recens, and GlycyrrhizaeRadix et Rhizoma; The main herbal medicines for Yangming diseases were Rhei Radix et Rhizoma, Ginseng Radix etRhizoma, and Armeniacae Semen Amarum; The main herbal medicines for Jueyin diseases were Zingiberis Rhizoma,Angelicae Sinensis Radix, and Asari Radix et Rhizoma; The main herbal medicine for Shaoyin diseases was AconitiLateralis Radix Praeparata and Poria; The main herbal medicine for Shaoyang disease was Xiaochaihu Decoction. Thecalculation results for common nodes between random two channel subnets showed that the prescriptions for Taiyang,Yangming, Jueyin, and Shaoyin diseases had similar herbal medicines. Data of medicinal subnets for Taiyin andShaoyang syndromes were few, and most of them consisted of prescriptions of other channel subnets combining withfew new herbal medicines. Conclusion There are differences in medication principles of six channel syndrome inTreatise on Cold Damage Disorders, which provide certain significance for the study on mechanism of syndromedifferentiation and treatment in Treatise on Cold Damage Disorders.

关 键 词：伤寒论 复杂网络 六经药物子网 拓扑分析 用药规律 

分 类 号：R222.2[医药卫生—中医基础理论] R2-05[医药卫生—中医学]