氟西汀联合血塞通注射液对脑卒中后抑郁病人脑血流灌注量的影响  

Effects of Fluoxetine and Xuesaitong Injection on the Cerebral Blood Flow in Patients with Post Stroke Depression

作　　者：杨训永[1] 刘建[1] Yang Xunyong;Liu Jian(Third People’s Hospital of Chengdu,Chengdu 610031,Sichuan,China)

机构地区：[1]四川省成都市第三人民医院,成都610031

出　　处：《中西医结合心脑血管病杂志》2016年第14期1658-1660,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨氟西汀联合血塞通注射液对脑卒中后抑郁病人脑血流灌注量的影响。方法将90例脑卒中后抑郁病人随机分为观察组与对照组,各45例,观察组采取氟西汀联合血塞通注射液治疗,对照组则给予氟西汀治疗,治疗8周后评价两组临床疗效及不良反应,同时治疗前后比较两组汉密尔顿抑郁量表(HAMD)评分、美国国立卫生研究院脑卒中量表(NIHSS)评分、简易精神状态量表(MMSE)评分及血流灌注相关指标。结果观察组治疗总有效率为93.33%,显著高于对照组的77.78%(P<0.05)。与治疗前比较,两组治疗8周HAMD评分、NIHSS评分及平均通过时间(MTT)均明显下降,MMSE评分、脑血流速度(CBF)、脑血流量(CBV)均明显上升,差异有统计学意义(P<0.05),且观察组治疗8周上述指标均明显优于对照组(P<0.05)。两组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论氟西汀联合血塞通注射液治疗脑卒中后抑郁,能明显改善病人抑郁症状,促进神经功能缺损及认知功能恢复,同时能明显改善病灶区域血流灌注情况。Objective To explore the effects of fluoxetine and Xuesaitong injection (XSTI)on cerebral blood flow in patients with post stroke depression(PSD).Methods Ninety patients with PSD were randomly divided into two groups:control group(n =45)treated with fluoxetine,and treatment group(n =45)treated with fluoxetine and XSTI for 8 weeks.The clinical efficacy and adverse reactions were evaluated.The scores of Hamilton Depression Scale(HAMD),National Institutes of Health Stroke Scale (NIHSS),Mini-Mental State Examination (MMSE)and blood perfusion related indexes were determined before and after the treatment.Results Total effective rate was 93.33% in treatment group,which was significantly higher than that in control group (77.78%,P <0.05).Compared with those before the treatment,the scores of HAMD,NIHSS scores and mean transit time (MTT)were decreased significantly in two groups after 8 weeks of treatment,while MMSE scores,cerebral blood flow (CBF)and cerebral blood volume (CBV)were increased significantly (P <0.05).Above indexes in treatment group after 8 weeks of treatment were significantly better than that in control group (P <0.05).There was no significant difference in the incidence of adverse drug reactions between two groups (P >0.05).Conclusion Fluoxetine and XSTI can improve patients’depressive symptoms significantly,promote recovery of neurological impairment and cognitive function,and can improve blood perfusion in lesions area significantly in patients with PSD.

关 键 词：脑卒中 抑郁 氟西汀 血塞通注射液 血流灌注 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]