结外NK/T细胞淋巴瘤鼻型34例临床分析  

Clinical Characteristic of 34 Patients with Extranodal Nasal Type NK/T-Cell Lymphoma

作　　者：聂波[1] 曾云[1] 李云涛[1] 李丽银[1] 杨弘[1] NIE Bo;ZENG Yun;LI Yun-Tao;LI Li-yin;YANG Hong(Dept. of Hematology,The 1st Affiliated Hospital of Kunming Medical University Hematopathy Research Center of Yunnan Province,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院血液内科,云南省血液病研究中心,云南昆明650032

出　　处：《昆明医科大学学报》2016年第6期123-126,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学联合专项基金资助项目(2014FB027)

摘　　要：目的分析结外NK/T细胞淋巴瘤鼻型的临床特点及治疗方案,提高对该特殊类型淋巴瘤的认识.方法对经病理证实的结外NK/T细胞淋巴瘤鼻型患者34例的临床资料进行回顾性的分析.结果 31例患者中,EB病毒(EBV)感染阳性组26例,近期疗效结果显示阳性组疗效显著低于阴性组(38.46%vs 87.50%;P<0.05).随访截至2015年10月,34例患者中,死亡19例.其中17例死于疾病复发或进展,2例死于其他疾病.15例患者生存,(其中11例无病生存),中位生存时间为37个月.患者2 a生存率与临床分期、B症状、EBV感染等有关(P值分别为0.017/0.001、0.005、0.039).结论 EB病毒感染与患者的治疗反应有关;患者的预后与临床分期、B症状、EBV感染等临床特征有关.Objective Analysis of clinical features and treatment of nasal type NK/T cell lymphoma, to improve the understanding of this special type of lymphoma.Method The clinical data of 34 patients with nasal type NK/T cell lymphoma confirmed by pathology were retrospectively analyzed.Result In 31 cases,26 cases were EB virus(EBV) infection positive,recent Treatment Effectiveness in the positive group was significantly lower than the negative group (38.46% vs. 87.50%; P<0.05) . Follow up showed until October 2015, 19 of 34 patients died. Among them, 17 cases died of disease relapse or progression, 2 cases died of other diseases. 15 patients survived (11 of them were disease-free) and the median overall survival time was 37 months. The 2 year overall survival was related to clinical stage, B symptoms, EBV infection (the P values were 0.017/0.001,0.005,and 0.039 respectively).Conclusion EBV infection is associated with patient's treatment response in NK/T-Cell Lymphoma; and the prognosis is associated with clinical features such as clinical stage, B symptom,and EBV infection.

关 键 词：结外NK/T细胞淋巴瘤 淋巴瘤 分期 治疗 预后 

分 类 号：R733.4[医药卫生—肿瘤]