CCK-8人工神经修复大鼠坐骨神经长段缺损的实验研究  

Experimental study on repairing sciatic nerve defect in rats with CCK-8 artificial nerve

作　　者：刘合庆[1] 巩孝勇 郝鹏 李连亭 Liu Heqing;Gong Xiaoyong;Hao Peng;Li Lianting(Department of Spinal Surgery,Municiple Hospital of Heze City,Shandong Province 274009;Zhuangzai Center Hospital of Cao County,Shandong Province 274000)

机构地区：[1]山东省菏泽市立医院脊柱外科,274009 [2]山东省曹县庄寨中心医院,274000

出　　处：《中国社区医师》2016年第19期9-10,共2页Chinese Community Doctors

摘　　要：目的:探索八肽胆囊收缩素对坐骨神经长段缺损修复的效果。方法:将Wistar大鼠分为A组和B组,A组给予导管内注射CCK-8治疗,B组注射生理盐水,12周后评价恢复程度。结果:A组运动行为学、再生神经外观形态、SFI%、NEP测定、组织学结构、有髓纤维计数恢复率测定七项指标皆优于B组,差异具有统计学意义(P<0.05)。结论:CCK-8可作为人工神经材料修复周围神经长段缺损。Objective:To explore the effect of cholecystokinin-octopeptide on repairing defect of sciatic nerve.Methods:Wistarrats were divided into the A group and the B group.The A group were treated with CCK-8 injection,while the B group wereinjected with normal saline.Then we evaluated the degree of recovery after 12 weeks.Results:In the A group,the indexes in theseven indexes of motor behavior,the morphology of the regenerated nerve,the SFI% ,the NEP determination,the histologicalstructure and the count and recovery rate of the pulp fibers were better than those of the B group,and the differences werestatistically significant(P<0.05).Conclusion:CCK-8 can be used as artificial neural defect material in repairing long peripheralnerve.

关 键 词：八肽胆囊收缩素 坐骨神经 长段缺损 复合组织神经导管 

分 类 号：R745.4[医药卫生—神经病学与精神病学]