Survivin、Caspase-9的表达与大肠癌关系的研究进展  

Research of the relationship between Survivin and Caspase-9 expression in colorectal cancer

作　　者：赵岩[1] 王志强[1] Zhao Yan;Wang Zhiqiang(Hongqi Hospital of Mudanjiang Medical College, Mudanjiang 157011, China)

机构地区：[1]牡丹江医学院红旗医院肿瘤科,157011

出　　处：《中华结直肠疾病电子杂志》2015年第6期645-647,共3页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：黑龙江省研究生创新科研项目(2014YJSCX-20)

摘　　要：大肠癌是当今严重威胁人类健康的疾病之一,它是多因素协同作用的结果,其中调控凋亡的基因异常表达在大肠癌发生、发展中起重要促进作用。Survivin和Caspase-9在调控细胞凋亡过程中存在关联,它们的异常激活及失活都与大肠癌的发生密切相关。先前的研究表明Survivin和Caspase-9与大肠癌的浸润、分化、分期、淋巴结转移的关系依然存在争议。两者在大肠癌的诊断、预后及靶向治疗方面具有应用前景。Colorectal cancer is one of the most serious threaten disease to human health. It is the result of many factors, the abnormal expression of the genes which regulate apoptosis play an important role in the development of colorectal cancer. Survivin and Caspase-9 are associated with the regulation of apoptosis, their abnormal activation and inactivation are closely related to the occurrence of colorectal cancer. Previous studies have indicated that the relationship between Caspase-9、Survivin and the invasion,differentiation, staging and lymph node metastasis of colorectal cancer remain exist controversy. There are clnical value in both of them in the aspects of diagnosis, prognosis and targeted therapy colorectal cancer.

关 键 词：大肠癌 凋亡 SURVIVIN CASPASE-9 

分 类 号：R735.34[医药卫生—肿瘤]