结直肠癌与肥胖等多种病因学的关系探讨  

The relationship among colorectal cancer, obesity and other etiologies

作　　者：姚慧静[1] 袁海鹏[1] Yao Huijing;Yuan Haipeng(Department of Gastroenterology, Tai′an Central Hospital, Tai′an 271000, China)

机构地区：[1]山东省泰安市中心医院消化内二科,271000

出　　处：《中华结直肠疾病电子杂志》2016年第4期319-322,共4页Chinese Journal of Colorectal Diseases(Electronic Edition)

摘　　要：目的肥胖被证实为增加结直肠癌发病风险的重要因素。本研究探讨BMI与结直肠癌发病的关系,为结直肠癌的预防提供参考。方法选取泰安市中心医院及泰山医学院附属医院202例首次确诊的结直肠癌患者和202名非癌症患者,分析比较两组患者BMI情况。结果首次确诊的结肠癌患者平均身体质量指数(body mass index,BMI)为25.1±3.5 kg/m2,对照组人群平均BMI为21.2±3.1 kg/m2,结直肠癌患者的BMI明显高于健康对照人群(t=-12.153,P<0.001)。结肠癌患者的BMI与健康对照组比较,在性别(P<0.05)、是否胆囊炎或胆囊切除病史(P<0.05)方面差异均有统计学意义。Logistic回归分析示,BMI值(t=12.171,P<0.001)、有胆囊炎或胆囊切除病史者(t=3.128,P=0.002)及性别(t=3.321,P=0.001)与结直肠癌的发病呈显著正相关关系,和是否糖尿病(t=1.260,P=0.208)及年龄(t=-1.790,P=0.074)与结直肠癌的发病不相关。结论结直肠癌的发生与BMI情况、是否患有胆囊病者和性别有关。Objective Obesity is associated with increased risk of colorectal cancer. Thisstudy was aiming to explore the relationship between BMI and colon cancer for prevention and treatment.Methods Clinical data including BMI of 202 colorectal cancer patients and 202 healthy population fromTai′an Central Hospital were analyzed. Results The mean BMI was significantly higher in colorectalcancer patients than in healthy populatioin (25.1±3.5 kg/m2, 21.2±3.1 kg/m2, t=-12.153, P < 0.001).When stratified by sex (P < 0.05), cholecystopathy (P < 0.05), the BMI was always higher in colon cancerpatients than in healthy group. Logistic regression analyses showed that BMI (t=12.171, P < 0.001),cholecystopathy (t=3.128, P=0.002) and sex (t=3.321, P=0.001) were important risk factors of coloncancer. The diabetes mellitus (t=1.260, P=0.208) and age (t=-1.790, P=0.074) are not associated withcolorectal cancer. Conclusion The occurrence of colorectal cancer is related to BMI, cholecystopathyand sex.

关 键 词：结直肠肿瘤 肥胖症 身体质量指数 

分 类 号：R735.34[医药卫生—肿瘤] R589.2[医药卫生—临床医学]