结直肠癌肝转移的可切除性判断  

Assessment of resectability of colorectal liver metastasis

作　　者：周鹏扬 王建伟[1] Zhou Pengyang;Wang Jianwei(Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China)

机构地区：[1]浙江大学医学院附属第二医院肿瘤外科,杭州310009

出　　处：《中华结直肠疾病电子杂志》2016年第5期390-397,共8页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金面上资助项目(No.81272677)

摘　　要：结直肠癌最好发的转移部位是肝脏,手术是治愈结直肠癌肝转移并获得长期生存的唯一可能方式。就目前多学科治疗背景下,高效能的化疗方案联合靶向药物以及多种手术方式,如传统二步肝切除联合门静脉栓塞术/门静脉结扎术(portal vein embolization,PVE/portal vein ligation,PVL)及联合肝脏劈离及门静脉结扎的二期肝切除(associating liver partition and portal vein ligation for staged hepatectomy,ALPPS)的出现,包括各种消融等局部治疗手段拓展了过去对于肝脏可切除性的定义,而依据新的可切除标准对于可切除性的判断仍存在较大差异,本文将就肝脏可切除性判断展开探讨。Liver is the most common site of metastasis in colorectal cancer. Hepatectomy as the treatment choice for patients seem to offer long-term survival and be the only chance for cure.The advent of aggressive interventions such as two-stage hepatectomy with portal vein embolization/ligation (PVE/PVL) and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), high-effective chemotherapy regimen associated with targeted medicine and various ablation treatments has expanded the definition of hepatic resectability. But according to the recent resectability standard, there are still considerable differences in surgical decision making. To further illustrate this issue, we therefore investigate the resectability of colorectal liver metastasis.

关 键 词：结直肠肿瘤 肿瘤转移 手术切缘 

分 类 号：R735.34[医药卫生—肿瘤]