脑出血患者血清NSE、GFAP、BDNF水平变化与认知障碍相关性研究  

Correlation of serum levels of NSE, GFAP, BDNF and cognitive impairment in patients with intracerebral hemorrhage

作　　者：刘宇明[1] 邓燕华[1] 许治强[1] 梁燕玲[1] 胡佳佳[1] 林永强[1] LIU Yu-ming;DENG Yan-hua;XU Zhi-qiang;LIANG Yan-ling;HU Jia-jia;LIN Yong-qiang(Department of Neurology,the Third Affiliated Hospital of Guangzhou Medical University, Guangdong 510150,China)

机构地区：[1]广州医科大学附属第三医院神经内科,广东510150

出　　处：《脑与神经疾病杂志》2016年第10期623-626,共4页Journal of Brain and Nervous Diseases

基　　金：广东省科技计划项目(2012B031800434)

摘　　要：目的探讨脑出血患者血清神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)、脑源性神经营养因子(BDNF)水平变化与认知障碍相关性。方法选择急性自发性脑出血患者100例,入院时均给予相应治疗,并进行NSE、GFAP、BDNF检测。将100例患者依据是否发生认知障碍分为认知障碍组(57例)和无认知障碍组(43例)。并比较不同损伤水平(MMSE评分)患者三个指标之间的差异、计算三个指标与MMSE水平的相关性。结果认知功能障碍组患者血清NSE、GFAP水平均显著高于无认知功能障碍组,BDNF显著低于无认知功能障碍组(t=7.039,t=2.247,t=4.847,P<0.01)。轻度损伤组、中度损伤组和重度损伤组间血清NSE、GFAP、BDNF水平存在显著差异(F=22.752,F=31.506,F=38.294,P<0.01)。血清NSE、GFAP水平与MMSE评分正相关(r=0.641,r=0.604,P<0.05),BDNF与MMSE评分负相关(r=0.582,P<0.05)。结论脑出血患者血清NSE、GFAP、BDNF水平与脑出血患者卒中后认知功能障碍密切相关,可用于判断脑出血患者认知功能障碍的严重程度。Objective To investigate the serum neuron specific enolase( NSE) and glial fibrillary acidicprotein( GFAP), brain derived neural nutrition factor( BDNF) level changes in cerebral hemorrhage patients andthe correlation with cognitive impairment. Method 100 cases of acute spontaneous cerebral hemorrhage wereselected, and the corresponding treatments were given in the hospital, the seru NSE, GFAP and BDNF were detected.100 patients were divided into cognitive impairment group( 57cases) and non cognitive impairment group( 43cases)according to whether there were cognitive impairment. Those three indicators were compared between different levelsof cognitive injury( MMSE score) group, and the correlation between the three indicators and MMSE. Results Theserum GFAP and NSE were significantly higher in the patients with cognitive impairment than those without cognitiveimpairment, and BDNF was significantly lower( t=7.039,t=2.247,t=4.847,P<0.01). The serum levels of NSE,GFAP and BDNF were significantly different in the mild injury group, moderate injury group and severe injury group(F=22.752, F=31.506, F=38.294, P<0.01). The levels of serum NSE and GFAP were positively correlated with MMSEscores( r=0.641, r=0.604, P<0.05), and BDNF was negatively correlated with MMSE scores( r=0.582, P<0.05).Conclusion The levels of serum NSE, GFAP and BDNF in patients with cerebral hemorrhage are closely related tocognitive dysfunction after stroke, which can be used to determine the severity of cognitive impairment in patients withcerebral hemorrhage.

关 键 词：脑出血 神经元特异性烯醇化酶 胶质纤维酸性蛋白 脑源性神经营养因子 认知障碍 

分 类 号：R743.34[医药卫生—神经病学与精神病学]